Pulse Radiolysis Kinetic Studies of the Self Decay of α-Hydroxyl Ethyl Peroxyl Radicals and Their Reactions with Quercetin and Pyrocatechol

Abstract

Abstract: Lipid Peroxidation(LPO) plays an important role in many pathological processes, while quercetin is an effective LPO inhibitor. α-Hydroxyl ethyl peroxyl radical was chosen to act as a model of lipid peroxyl radical in the kinetic studies of its reaction with quercetin and pyrocatechol. The 1st and 2nd order decay rates of αhydroxyl ethyl peroxyl radical in ethanol solution were obtained for the first time to be (40.4±2.6) s^-1 and (6.9±0.9)×10⁸ mol^-1·L·s^-1, respectively. The rate constant of the reaction between αhydroxyl ethyl peroxyl radical and quercetin was determined to be (2.1±0.3)×10⁷ mol^-1·L·s^-1 through pulse radiolysis studies. Pyrocatechol was chosen to act as a model compound of polyphenols and its reaction with αhydroxyl ethyl peroxyl radical was studied. The rate constant of the reaction between α-hydroxyl ethyl peroxyl radical and pyrocatechol was determined to be (3.1±0.1)×10⁵ mol^-1·L·s^-1.

Key words: Quercetin, Pyrocatechol, α-Hydroxyl ethyl peroxyl radical, Pulse radiolysis, Kinetics

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ZHANG Fu-Gen, WU Ji-Lan, LI Feng-Mei, LIU An-Dong . Pulse Radiolysis Kinetic Studies of the Self Decay of α-Hydroxyl Ethyl Peroxyl Radicals and Their Reactions with Quercetin and Pyrocatechol[J]. Chem. J. Chinese Universities, 2002, 23(3): 461.

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Pulse Radiolysis Kinetic Studies of the Self Decay of α-Hydroxyl Ethyl Peroxyl Radicals and Their Reactions with Quercetin and Pyrocatechol

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