Isolation and Identification of Etofesalamide-2-glucuronide

Abstract

Abstract: Preparation of glucuronide conjugates of etofesalamide[N-(4-ethoxyphenyl)-2-hydroxyl-benzamide], a novel drug for acne therapy, in rabbit was discribed. Urine samples from 0 to 12 h were collected after single oral administration of 400 mg etofesalamide to two rabbits. The samples were lyophilized and extracted with methanol, and then etofesalamide-2-glucuronide in them was prepared with semipreparative HPLC. The molecular structure of this compound was confirmed by electrospray ion trap mass spectrometry and ¹H NMR.

Key words: N-(4-Ethoxyphenyl)-2-hydroxyl, benzamide, Etofesalamide-2-glucuronide, HPLC, Electrospray ion trap mass spectrometry

CLC Number:

O656.4
R969.1

TrendMD:

CHU Da-Feng, GU Jing-Kai, ZHONG Da-Fang, SI Duan-Yun, ZHOU Hui . Isolation and Identification of Etofesalamide-2-glucuronide[J]. Chem. J. Chinese Universities, 2002, 23(3): 376.

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Isolation and Identification of Etofesalamide-2-glucuronide

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