Synthesis and Spectroscopic Analysis of 2',3'-O-Ethoxymethylidene Adenosine 5'-Thiophosphoramidates

Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (12): 2284.

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Synthesis and Spectroscopic Analysis of 2',3'-O-Ethoxymethylidene Adenosine 5'-Thiophosphoramidates

MIAO Zhi-Wei¹, FENG Yu-Ping¹, FU Hua¹, TU Guang-Zhong², ZHAO Yu-Fen¹

1. The Key Laboratory of Bioorganic Phosphorus Chemistry, Ministry of Education, Department of Chemistry, School of Life Sciences and Engineering, Tsinghua University, Beijing 100084, China;
2. Beijing Institute of Microchemistry, Beijing 100091, China

Received:2001-10-24 Online:2002-12-24 Published:2002-12-24

Abstract

Abstract: Nucleoside reverse transcriptase inhibitors are the only drugs so far approved for the treatment of AIDS. Several nucleoside analogs are potent inhibitors of human immunodeficiency virus(HIV) in cell culture. However, in many cases the nucleoside derivatives have a poor affinity for nucleoside kinases. Nucleoside 5'-phosphorothioates is relatively resistant to enzymatic transformations. In this paper, 2',3'-O-alkoxymethylidene adenosine 5'-thiophosphoramidates were synthesized through a highly efficient approach. The new compounds were characterized by NMR, IR and ESI-MS.

Key words: O-Ethoxymethylidene adenosine 5'-thiophosphoramidate, Synthesis, Spectroscopic analysis

CLC Number:

O621.15

TrendMD:

MIAO Zhi-Wei, FENG Yu-Ping, FU Hua, TU Guang-Zhong, ZHAO Yu-Fen. Synthesis and Spectroscopic Analysis of 2',3'-O-Ethoxymethylidene Adenosine 5'-Thiophosphoramidates[J]. Chem. J. Chinese Universities, 2002, 23(12): 2284.

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Synthesis and Spectroscopic Analysis of 2',3'-O-Ethoxymethylidene Adenosine 5'-Thiophosphoramidates

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