Chem. J. Chinese Universities ›› 2002, Vol. 23 ›› Issue (11): 2102.

• Articles • Previous Articles     Next Articles

Synthesis and Steric Structure of α-Amino-β-lactam Derivatives of 1,5-Benzothiazepines

ZHANG Ping, HAO Zhen-Fang, LI Yuan   

  1. Department of Chemistry, Hebei Normal University, Shijiazhuang 050016, China
  • Received:2001-09-11 Online:2002-11-24 Published:2002-11-24

Abstract: Benzothiazepines reacted with a new N-protected agent of glycine to give the title compounds. The configuration and conformation of the products were determined by X-ray crystal analysis. The results also revealed that the reaction was stereospecific. The two substituents at β-lactam were on the same side, the seven-membered ring was in chair-like conformation.

Key words: Benzothiazepine, β-Lactam, N-[(Chloroformyl)methyl]succimide, Synthesis

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