Chiral Separation on Naproxen and Determination of Chromatography Equilibrium Constant Using Molecular Imprinting

Abstract

Abstract: A chiral stationary phase for naproxen separation was prepared by means of molecular imprinting, in which acrylamide and ethylene glycol dimethacrylate were copolymerized in the presence of template. Racemic naproxen was efficiently resolved on the molecular imprinting polymer. The concentration of acetic acid in the mobile phase was optimized. A new affinity chromatography model using molecular imprinting was established by which the agreement between the simulated and experimental results was obtained. The results suggested that affinity chromatography mechanism controled the retention in this system.

Key words: Molecular imprinting polymer, Chiral separation, Naproxen, Affinity adsorption

CLC Number:

O657.32

TrendMD:

LEI Jian-Du, TAN Tian-Wei . Chiral Separation on Naproxen and Determination of Chromatography Equilibrium Constant Using Molecular Imprinting[J]. Chem. J. Chinese Universities, 2002, 23(11): 2073.

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Chiral Separation on Naproxen and Determination of Chromatography Equilibrium Constant Using Molecular Imprinting

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