Studies of Applications of a New Matrix——α-Cyano Ferulic Acid in MALDI-TOFMS

Abstract

Abstract: This paper reports for the first time an experiment designed in which synthesized α-cyano ferulic acid used as a new matrix for the analysis of cytochrome c, trypsin, bovine serum albumin, β-cyclodextrin, dextrans and DNAd(T)₁₈. The results demonstrated that α-cyano ferulic acid used as a new matrix could effectively desorb and ionize different kinds of samples, such as proteins and peptides, oligosaccharides, polysaccharides and oligonucleotides. In analysis of dextrans the new matrix gave better results when comparing with the normally used DHB. In analysis of DNAd(T)₁₈, the sample could be desorbed and ionized more efficiently even without_sample purification, which is normally needed when using 3-HPAas a matrix.

Key words: Cyano ferulic acid, Matrix, MALDI TOFMS

CLC Number:

O657.63

TrendMD:

DENG Hui-Min, ZHA Qing-Min, LI Jun, SHAO Wei-Yan, LAI Zhi-Hui, ZHAO Shan-Kai . Studies of Applications of a New Matrix——α-Cyano Ferulic Acid in MALDI-TOFMS[J]. Chem. J. Chinese Universities, 2001, 22(7): 1102.

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Studies of Applications of a New Matrix——α-Cyano Ferulic Acid in MALDI-TOFMS

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