Asymmetric Addition of Diethyl Zinc to Aldehyde Catalyzed by Chiral Ti(Ⅳ)/Schiff Base Polymer

Abstract

Abstract: New Schiff base chiral polymers was synthesized. The asymmetric addition of diethyl zinc to aldehyde was achieved catalyzed by Ti(Ⅳ)/polymer which was formed in situ from chiral polymer and Ti(O-i-Pr)_4. Optical alcohols were obtained in a high yield with e.e. up to 84.5%. The effects of temperature, complex time, structure of substrate etc. on the catalytic activity and enantio selectivity were studied in detail. The reaction mechanism was proposed.

Key words: Schiff base, Chiral polymer, Asymmetric addition

CLC Number:

O621

TrendMD:

DONG Chun-E, ZHANG Jun-Long, ZHENG Wei-Zhong, ZHI Yong-Gang, ZHANG Liang-Fu, YU Zuo-Long . Asymmetric Addition of Diethyl Zinc to Aldehyde Catalyzed by Chiral Ti(Ⅳ)/Schiff Base Polymer[J]. Chem. J. Chinese Universities, 2001, 22(5): 779.

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Asymmetric Addition of Diethyl Zinc to Aldehyde Catalyzed by Chiral Ti(Ⅳ)/Schiff Base Polymer

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