Nuclear Magnetic Resonance Studies on the Effects of Rare Earth in Rats Urine

Abstract

Abstract: Male Wistar rats were administrated orally with La(NO₃)₃ at doses of 0.05, 0.2, 2.0,10 and 20 mg/kg body weight. Urine was collected over a 24 h period after dosing. Resonances for a large number of low molecular weightmetabolites were assigned in a high resolution₁H NMRspectra of rat urine. The variation of some low molecular weightmetabolites in urine provided a sensitive measurement of Rare Earth induced renal and liver lesions, in which DMA, DMG, urea, Kg, TMAO, succinate, citrate and amino acids have been suggested as NMRmarkers for renal damage and ethanol, lactate, taurine as the markers for liver damage. The method could be applicable to study of the toxicological effects of other compounds and drugs.

Key words: Rare Earth, Urine, Nuclear magnetic resonance, Toxicological effects

CLC Number:

O657.2

TrendMD:

LI Xiao-Jing, FENG Jiang-Hua, PEI Feng-Kui, CHEN Xi, LI Shu-Lei, NIE Yu-Xiu . Nuclear Magnetic Resonance Studies on the Effects of Rare Earth in Rats Urine[J]. Chem. J. Chinese Universities, 2001, 22(11): 1904.

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Nuclear Magnetic Resonance Studies on the Effects of Rare Earth in Rats Urine

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