Chem. J. Chinese Universities ›› 2000, Vol. 21 ›› Issue (1): 70.

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Studies on Carbohydrates(ⅩⅩⅪ)——Synthesis of Spacer-armed Lactoses and Their Dimers

LI Qing1, CAI Meng-Shen1, LI Zhong-Jun1, ZHOU RouLi2   

  1. 1. Department of Bioorganic Chemistry, School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, China;
    2. Departmentof Cell Biology, Schoolof Basic Medical Science, Beijing Medical University, Beijing 100083, China
  • Received:1999-03-26 Online:2000-01-24 Published:2000-01-24

Abstract: Octaacetyllactose was used as glycosylation donor which reacted with diethylene glycol or triethylene glycol to give corresponding spacer-armed lactoses and dimers 2, 3, 6, 7, then they were deprotected to give target compounds 4, 5, 8, 9 which can be used for studies on anti-tumor metastasis as well as relationship of structure-activity.

Key words: Lactose, Spacer-arm, Dimer, Anti-tumor metastasis

CLC Number: 

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