Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (9): 1409.

• Articles • Previous Articles     Next Articles

Synthesis, Structure and Spectral Properties of 1, 5-Benzothiazepines-α-phenyl-β-lactams

LI Yuan1, DU Cai-Yun2, JIN Sheng3   

  1. 1. Department of Chemistry, Hebei Normal University, Shijiazhuang 050016 China;
    2. Department of Basic Course, Handan Agricultural College, Handan 057150 China;
    3. Institute of Chem , and Molecular Engineering University, Peking University, Beijing 100871, China
  • Received:1998-11-05 Online:1999-09-24 Published:1999-09-24

Abstract: Four title compounds were synthesized, their spectral properties including IR,MS, 1HNMR and their steric structures were studied.The conformation of the seven-mem-bered ring is chair-like and the two phenyl substituents on the β-lactam ring adopt cis configuration.It is proposed that the reaction of 1,5-benzothiazepines with acyl chloride is a stereospecific one.

Key words: 1,5-Benzothiazepine, Phenyl-β-lactam, Stereospecific one

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