Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (9): 1394.

• Articles • Previous Articles     Next Articles

The Synthesis of (+)-1S, 2R, 5S-8-β-Naphthylmenthol from R-(+)-Pulegone

HUANG Guo-Bin, WU Ke-Mei, HUANG Liang   

  1. Institute of Meteria Medica, Chinese Academy of Medical Sciences &Peking Union Medical College, Beijing 100050, China
  • Received:1999-02-07 Online:1999-09-24 Published:1999-09-24

Abstract: The chiral auxiliary (+)-1S, 2R, 5S-8-β-naphthylmenthol and its epimer (-)-1R,2R, 5S-8-β-naphthylneomenthol were synthesized by 1, 4-addition, bromination, hydrolysis,oxidation and so on from R-(+)-pulegone in 24.0% and 22.6% overall yield.

Key words: (+)-1S, 2R, 5S-8-β-naphthylmenthol, R-(+)-Pulegone, Chiral auxiliary

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