Chem. J. Chinese Universities ›› 1999, Vol. 20 ›› Issue (8): 1224.

• Articles • Previous Articles     Next Articles

Synthesis of Two New Chiral Blocks for the Construction of Peptide Nucleic Acid(PNA)

ZHANG Li-Gang, MIN Ji-Mei, ZHANG Li-He    

  1. National Laboratory of Natural and Biomimetic Drugs, Beijing Medical University, Beijing 100083, China
  • Received:1999-01-11 Online:1999-08-24 Published:1999-08-24

Abstract: Protected (L-) and (D-)-lysine were used respectively as starting materials to syn-thesize two new types of chiral blocks for the construction of PNA. Nucleobase was linked to α-NH2 of lysine via _CH2C(O)_ spacer in type Ⅰ, and _C(O)_ was used in type Ⅱ.

Key words: Peptide nucleic acid (PNA), Lysine, Synthesis

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