Synthesis and Preliminary Bio-activity Studies of α-Pyrazyl-N phenyl-α-aminophosphonates

Abstract

Abstract: Aseries of α-pyrazyl-N-phenyl-α-aminophosphonates was synthesized by the reaction of phosphites with Schiff bases prepared through condensation of substituted anilines with 5-chloro-1-benzyl-3-methyl-4-pyrazylaldehyde. The reaction can be easily carried out without solvent. The two alkoxyl groups linking to phosphorus atom show unequivalent behavior in ¹HNMR. The structures of compounds were confirmed by IR, ¹HNMR and elemental analysis. The preliminary bioassay shows that some of them possess good fungicide and anti virus activities on some plants.

Key words: α-Aminophosphonates, Pyrazole, Bio-activity

CLC Number:

O626.12

TrendMD:

ZHANG Ke-Sheng, MU Lin-Jing, LONG Yun-Xian . Synthesis and Preliminary Bio-activity Studies of α-Pyrazyl-N phenyl-α-aminophosphonates[J]. Chem. J. Chinese Universities, 1999, 20(5): 741.

[1]	LI Kangming, LI Yansai, YI Yangjie, XU Leitao, YE Jiao, OU Xiaoming, LI Jianming, HU Aixi. Design, Synthesis and Biological Activity of 5-Pyrazole Carboxamides ^† [J]. Chem. J. Chinese Universities, 2020, 41(4): 716.
[2]	DONG Xinrui, XIA Zhe, WANG Zhenxue, BIAN Qiang, LI Huabin. Design， Synthesis and Biological Activity of Pyrazole-4-carboxamides Compounds Containing 1，2，4，5-Tetrasubstituted Phenyl [J]. Chem. J. Chinese Universities, 2020, 41(12): 2759.
[3]	HU Xiaoyang, SU Dongping, LI Shimeng, WANG Zhipeng, ZHANG Lirong, LIU Ying, SONG Lianjun, CHEN Zhili, DING Songdong. Extraction of Am(Ⅲ) and Eu(Ⅲ) from Nitric Acid Solution with the Pyridylpyrazole Based Ligand C8-BPP [J]. Chem. J. Chinese Universities, 2017, 38(8): 1324.
[4]	ZHANG Chenglu, SUN Xiaona, LI Chuanyin, CAI Jiying, WANG Jing, LI Yizheng, WANG Huayu. Synthesis and Bioactivities Evaluation of Novel 1-(1,3,5-Triazin-6-yl)-3-methyl-4-(5-phenyl-1,3,4-oxadiazol-2-yl) pyrazole^† [J]. Chem. J. Chinese Universities, 2017, 38(10): 1764.
[5]	ZHANG Luge, XUE Zexu, ZHANG Chong, YAN Hui. Molecular Dynamics Studies on the Selective Deposition of 3(5)-(9-Anthryl) Pyrazole onto Self-assembled Monolayers^† [J]. Chem. J. Chinese Universities, 2016, 37(3): 505.
[6]	WANG Zhinan, WANG Jixiao, SONG Jian, GAO Xue, FENG Xiaodong, SUN Lixian, XING Yongheng. Syntheses, Structures and Photocatalytic Activities of Coordinated Supramolecular Complexes Containing Triazin-pyrazole Ligand^† [J]. Chem. J. Chinese Universities, 2015, 36(8): 1478.
[7]	WANG Zijian, SUN Xiaohong, LIU Yuanfa, CHEN Bang, SHEN Shengqiang, JIN Ruyi, MA Haixia. Synthesis and Biological Activities of 1,2,4-Triazole Schiff Bases Containing Pyrazole Rings^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1315.
[8]	LI Heng-Dong, SU Xiao-Long, CHEN Ping-Hua, XIE Li-Li, YUAN Yao-Feng. Synthesis and Properties of 5-Ferrocenyl-pyrazoline Derivatives [J]. Chem. J. Chinese Universities, 2013, 34(7): 1653.
[9]	LI Chun-Yan, ZHUO Ji-Bin, XIE Li-Li, LI Heng-Dong, WANG Wen-Feng, YUAN Yao-Feng*. Synthesis and Crystal Structure of 3-Ferrocenyl-5-aryl-1-benzenesulfonyl Dihydropyrazole Derivatives [J]. Chem. J. Chinese Universities, 2011, 32(6): 1305.
[10]	LI Miao, ZHANG Jin-Bo, YANG Ji-Chun, LI Zhi-Nian, LIU Chang-Ling, LI Zheng-Ming. Design, Synthesis and Bioactivity of New N-Methoxycarbamate Containing Pyrazole [J]. Chem. J. Chinese Universities, 2009, 30(7): 1348.
[11]	SHEN Fu-Gang, DUAN Wen-Yong, SUN Hong-Wei, CHEN Lan, CHEN Pei-Quan, LAI Cheng-Ming, LI Zheng-Ming. Density Functional Theory Study on the Reactions of Pyrazole Derivatives with CH₃I [J]. Chem. J. Chinese Universities, 2006, 27(11): 2175.
[12]	ZOU Xiao-Mao, WU Chao, ZHOU Chuan-Zheng, REN Xue-Ling, YANG Hua-Zheng . Synthesis and Biological Activity of 3-Pyrimidylamino-pyrazoles [J]. Chem. J. Chinese Universities, 2005, 26(3): 456.
[13]	GUO Hui, HAN Jie, PANG Mei-Li, MA Yu-Xin, MENG Ji-Ben . Synthesis and Characterization of Acrylic Ester Bridged γ-Substituted β-Diketone Pyrazole and Isoxazole Derivatives [J]. Chem. J. Chinese Universities, 2005, 26(10): 1845.
[14]	CHENG Yong-Hao, ZOU Xiao-Mao, GAO Ying, YANG Hua-Zheng. Synthesis and Biological Activity of Novel 1-(Substituted-pyrazole-4-carbonyl) Pyrazoles [J]. Chem. J. Chinese Universities, 2004, 25(11): 2024.
[15]	ZHOU Yu-Han, MIAO Wei-Rong, CHENG L-Bai, WANG Da-Xiang, BAI Zai-Su . Synthesis and Herbicidal Activity of Substituted Phenyl Pyrazole Derivatives [J]. Chem. J. Chinese Universities, 2003, 24(7): 1225.

Synthesis and Preliminary Bio-activity Studies of α-Pyrazyl-N phenyl-α-aminophosphonates

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments