Studies on Artificial Imitation of Glutathione Peroxidase by Using Selenium containing β-Cyclodextrin

Chem. J. Chinese Universities ›› 1998, Vol. 19 ›› Issue (9): 1446.

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Studies on Artificial Imitation of Glutathione Peroxidase by Using Selenium containing β-Cyclodextrin

LIU Jun-Qiu¹, NING Yun-Gang¹, SHI Cheng-Bo¹, LUO Gui-Min¹, YAN Gang-Lin¹, SHEN Jia-Cong²

1. The Laboratory of Enzyme Engineering, Jilin University, Chang chun, 130023;
2. Key Laboratory for Supramolecular Spectra & Structure, Jilin University, Chang chun, 130023

Received:1997-08-30 Online:1998-09-24 Published:1998-09-24

Abstract

Abstract: 6-Selenium bridged cyclodextrin was synthesized by regioselective tosylation of β-cyclodextrin and NaHSe displacement on the basis of the active site structure of glutathione peroxidase(GPX). The compounds displayed a higher activity of GPXthan Ebselen(PZ51), its GPXactivity was 4.3 times more than that of PZ51. The structure of the mimic was characterized by elemental analysis, IRand ¹HNMR. The Se content and its valence in the mimic was determined by X-ray photoelectron spectrum.

Key words: Selenium, β-Cyclodextrin, Imitating enzyme, Glutathione peroxidase

CLC Number:

O641.4

TrendMD:

LIU Jun-Qiu, NING Yun-Gang, SHI Cheng-Bo, LUO Gui-Min, YAN Gang-Lin, SHEN Jia-Cong . Studies on Artificial Imitation of Glutathione Peroxidase by Using Selenium containing β-Cyclodextrin[J]. Chem. J. Chinese Universities, 1998, 19(9): 1446.

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Studies on Artificial Imitation of Glutathione Peroxidase by Using Selenium containing β-Cyclodextrin

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