Syntheses of Poly(phosphate-urethane)s as Drug Release Materials

Abstract

Abstract: New biodegradable and biocompatible copolymers poly (phosphate-urethane) swith elevated molecular weight were synthesized by the polycondensation of Ser-Tyr orTyr-Tyr dipeptide and phosphorodichloridate and followed by reacting with 1,4-butane-di-isocyanate.The chemical structures were confirmed by ¹HNMR, FTIRand elemental analy-sis.The molecular weight, and thermostability of these polymers were investigated.The invitro degradation and bovine serum albumin (BSA) release profile were also studied.It wasfound that the degradation rate of the materials and BSArelease behavior can be modulatedby varying the hydrohobic properties of these poly(phosphate-urethane)s.

Key words: Poly(phosphate-urethanes), Biodegradable property, Biocompatibility, Drug re-lease materials

CLC Number:

O633.14

TrendMD:

ZHUO Ren-Xi, WANG Jun, MAO Hai-Quan. Syntheses of Poly(phosphate-urethane)s as Drug Release Materials[J]. Chem. J. Chinese Universities, 1997, 18(7): 1207.

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Syntheses of Poly(phosphate-urethane)s as Drug Release Materials

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