Chem. J. Chinese Universities ›› 1997, Vol. 18 ›› Issue (1): 76.

• Articles • Previous Articles     Next Articles

Synthesis and Bioactivity of 1-(Substituted silylmethylthio)methyl-2, 8, 9-trioxa-5-aza-1-silabicyclo[3.3.3]undecanes

HE Zheng-Jie, LI Zheng-Ming, YANG Zhi-Qiang   

  1. Elemento-Orgamc Chemistry Institute, Nankai Uniuersity, Tianjin, 300071
  • Received:1996-01-03 Online:1997-01-24 Published:1997-01-24

Abstract: By the reactlon of (substituted silyl)methanethiols with 1-chloromethyl-2, 8, 9-tri-oxa- 5-aza-1-silabicyclo [3.3, 3] undecane, eleven novel organosilicon compounds were syn-thesized.Their structures were confirmed by 1HNMR, MSand elementary analysis.Arare rearrangement breakdown pattern was found ln their mass spectra.Preliminary bioassay re-sults showed these compounds have some antitumor activity.

Key words: Organosilicon compound, Synthesis, Bioactivity

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