Chem. J. Chinese Universities ›› 1996, Vol. 17 ›› Issue (8): 1235.

• Articles • Previous Articles     Next Articles

Synthesis of Some 4-(Un) Substituted Benzyl Piperazine-2,6-diones

QIN Zhao-Hai1, CHEN Fu-Heng1, XIE Yu-Yuan2   

  1. 1. Institute of Applied Chemistry, Beijing Agricultural University, Beijing 100094;
    2. Shanghai Institute of Materia Medica, Medica, Academia Sinica
  • Received:1995-08-12 Online:1996-08-24 Published:1996-08-24

Abstract: The development of several methods for the synthesis of four classes of 1,4-disubstituted piperazine-2,6-diones which have chelating effects or latent chelating effects is described.Some of them are proved to be considerably effective against P388 cells in vitro.

Key words: Piperazine-2,6-dione, Synthesis, Anticancer

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