Synthesis of α-Oxo-α-(1H-1,2,4-triazo-1-yl) Ketene N,S-Acetals and Their Biological Activities

Chem. J. Chinese Universities ›› 1995, Vol. 16 ›› Issue (10): 1555.

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Synthesis of α-Oxo-α-(1H-1,2,4-triazo-1-yl) Ketene N,S-Acetals and Their Biological Activities

LI Zheng-Ming, HUANG Zhen-Nian

Institute of Elemento-Organic Chemistry Nankai University, Tianjin, 300071

Received:1994-10-25 Revised:1995-03-09 Online:1995-10-24 Published:1995-10-24

Abstract

Abstract: The reaction of α-(1H-1,2,4-Triazol-1-yl) substituted acetophenone with isothiocyanate in the presence of a base and subsequent alkylation afforded twenty-six new α-ox-oketene N,S-acetals containing 1H-1,2,4-Triazole. Their structures were confirmed by IR,¹HNMR, elementary analysis. The preliminary biological test showed that some componds obtained have plant-regulatory activities.

Key words: 1H-1,2,4-Triazole, Ketene acetal, Synthesis, Biological activities

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LI Zheng-Ming, HUANG Zhen-Nian . Synthesis of α-Oxo-α-(1H-1,2,4-triazo-1-yl) Ketene N,S-Acetals and Their Biological Activities[J]. Chem. J. Chinese Universities, 1995, 16(10): 1555.

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Synthesis of α-Oxo-α-(1H-1,2,4-triazo-1-yl) Ketene N,S-Acetals and Their Biological Activities

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