CJCU

Chem. J. Chinese Universities ›› 1994, Vol. 15 ›› Issue (2): 220.

• Articles • Previous Articles     Next Articles

Studies on Condensed Heterocyclic Compounds(X)──Synthesis and Biological Activities of 3-Aryl-6-benzoylamino-striazolo[3,4-b]-1,3,4-thiadiazoles

ZHANG Zi-Yi1,2, LI Ming1,2, ZHAO Lan1,2, LI Zheng-Ming3, LIAO Ren-An3   

  1. 1. Elemento-organic Chemistry Laboratory, Nankai University, Tianjin, 300071;
    2. Deparment of Chemistry, Lanzhou University, Lanzhou, 730000;
    3. The Research Institute of Elemento-Organic Chemistry, Nankai University, Tianjin
  • Received:1993-03-02 Revised:1993-09-07 Online:1994-02-24 Published:1994-02-24

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Abstract: S-triazolo[3,4-b]-1,3,4-thiadiazoles are fused heterocyclic derivatives showing various biological effect, such as antifungal, antibacterial, hypotensive and CNSdepressant.In view of the pharmacological and synthetic interests of this kind of fused heterocycles, we investigate the reaction of 3-aryl-4-amino-5-mercapto-1,2,4-s-triazoles 1a-j with benzoyl isothiocyanate in the presence of absolute acetone and obtained a series of 3-aryl-6-benzoylamino-s-triazolo[3,4-b]-1,3,4-thiadiazoles,2a-j, whose structures were determined by elemental analysis, IR, 1H NMR and MS.The possible mechanism of this reaction has been suggested in the meantime.It was found that the representative compound 2h has moderate herbicidal activity.

Key words: S-triazolo[3,4-b]-1,3,4-thiadiazoles, Synthesis, Mechanism, Biological activity

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