Syntheses of New Poly phosphates as Drug Release Materials

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (12): 1743.

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Syntheses of New Poly phosphates as Drug Release Materials

MAO Hai-Quan¹, ZHUO Ren-Xi¹, FAN Chang-Lie¹, FAN Li-Hong¹, FU Ya-Ping²

1. Department of Chemistry, Wuhan University, Wuhan, 430072;
2. Experimental Center, Hubei Medical College, Wuhan, 430071

Received:1992-12-04 Revised:1993-07-20 Online:1993-12-24 Published:1993-12-24

Abstract

Abstract: New polyphosphates with amphiphilic structures were synthesized by solution poly-condensation using tyrosine alkyl esters and alkyl phosphodichloridates as monomers.Their structures were confirmed by NMR, FTIRand elemental analysis.The average molecular weight, intrinsic viscosity and thermostability of these polyphosphates were investigated.The in vitro degradation and protein (BSA) release profile were also studied.

Key words: Polyphosphate, Tyrosine alkyl ester, Amphiphilicity, Drug release material

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MAO Hai-Quan, ZHUO Ren-Xi, FAN Chang-Lie, FAN Li-Hong, FU Ya-Ping. Syntheses of New Poly phosphates as Drug Release Materials[J]. Chem. J. Chinese Universities, 1993, 14(12): 1743.

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Syntheses of New Poly phosphates as Drug Release Materials

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