Syntheses of (3-Benzyl-4-aroyl-l,2?-triazole-5-yl) (5-phenyI-l, 3,4-oxadiazole-2-yl) Sul fides

Chem. J. Chinese Universities ›› 1993, Vol. 14 ›› Issue (10): 1383.

• Articles • Previous Articles Next Articles

Syntheses of (3-Benzyl-4-aroyl-l,2?-triazole-5-yl) (5-phenyI-l, 3,4-oxadiazole-2-yl) Sul fides

FENG Xiao-Ming¹, CHEN Rong¹, ZHANG Zi-Yi²

1. Department of Chemistry, Southwest Normal University, Chongqing, 630715;
2. Department of Chemistry, Lanzhou University, Lanzhou

Received:1992-11-27 Revised:1993-05-03 Online:1993-10-24 Published:1993-10-24

Abstract

Abstract: Thirteen new (3-benzyl-4-aroyl-1, 2, 4-triazole-5-yl) (5-phenyl-1, 3, 4-oxadiazole-2-yl) sulfides (2) have been synthesized from the nucleophilic displacement of 3-benzyl-4-aroyl-1, 2,4-triazole-5-hydrosulfuryl anion on the 2-position of 2-methylsulfonyl-5-phenyl-1,3, 4-oxadia-zole.The structures of all compounds 2 were confirmed by elemental analysis, IR, ¹H NMRand MS.Compounds 2 were screened for their antifungal activity against E.Coli at 0.01%.The results show that some compounds 2 have stronger inhibiting effects.

Key words: 1,2,4-Triazole,1,3,4-Oxadiazole, Nucleophilic displacement, Antifungal activity

TrendMD:

FENG Xiao-Ming, CHEN Rong, ZHANG Zi-Yi. Syntheses of (3-Benzyl-4-aroyl-l,2?-triazole-5-yl) (5-phenyI-l, 3,4-oxadiazole-2-yl) Sul fides[J]. Chem. J. Chinese Universities, 1993, 14(10): 1383.

[1]	ZUO Huailong, LEI Simin, ZHANG Rui, LI Yuxin, CHEN Wei. Design， Synthesis and Antifungal Activity of Novel Isoquinoline Derivatives [J]. Chem. J. Chinese Universities, 2021, 42(9): 2766.
[2]	HE Feng,BAI Jinhai,CHEN Shuxian,TAN Xiaobei. Antifungal Activity and Mechanism of an Essential Oil from Eremothecium ashbyii^† [J]. Chem. J. Chinese Universities, 2019, 40(2): 272.
[3]	MU Boshuai, CHANG Suna, BIAN Yanqing, LI Yuan. Asymmetric Synthesis and Antibacterial Activity of Chiral 2-Methoxycarbonyl-4-fluorophenyl-1,5-benzothiazepines^† [J]. Chem. J. Chinese Universities, 2017, 38(3): 413.
[4]	CHEN Wei, WEI Wei, LIU Ming, HUA Xuewen, LI Yuxin, LI Yonghong, ZHANG Xiao, LI Zhengming. Design, Synthesis and Biological Activity of Novel Sulfonylurea Derivatives Containing Dimethoxymethyl-substituted Pyrimidine Moiety^† [J]. Chem. J. Chinese Universities, 2015, 36(7): 1291.
[5]	CHEN Wei, WEI Wei, ZHOU Sha, LI Yonghong, ZHANG Xiao, TONG Jun, LI Yuxin, LI Zhengming. Design, Synthesis and Biological Activity of Novel Sulfonylurea Derivatives Containing Phenyl-substituted Pyrimidine Moiety^† [J]. Chem. J. Chinese Universities, 2015, 36(4): 672.
[6]	ZHANG Jing, MU Boshuai, WU Meng, BIAN Yanqing, LI Yuan. Synthesis, Antifungal Activity and Structure-activity Relationship of -Fluorophenyl-2,3-dihydro-1,5-benzothiazepines Derivatives^† [J]. Chem. J. Chinese Universities, 2015, 36(4): 687.
[7]	KANG Wang, BU Huijuan, LI Wenhong, LI Yuan. Preliminary Structure-activity Relationship of 2-Ethoxycarbonyl-4-aryl-1,5-benzothiazepines with Antifungal Activity^† [J]. Chem. J. Chinese Universities, 2014, 35(4): 766.
[8]	FAN Shili, ZHANG Bo, GAO Liye, WANG Lanzhi, BIAN Yanqing, LI Yuan. Synthesis, Antifungal Activity and Structure-activity Relationship of 2-Methoxycarbonyl/ethoxycarbonyl-4-fluorophenyl-1,5-benzothiazepines^† [J]. Chem. J. Chinese Universities, 2014, 35(12): 2574.
[9]	LIU Zhuo, PAN Li, YU Shu-Jing, LI Zheng-Ming. Synthesis and Antifungal Activity of N-(4'-Substituted aromatic pyrimidin-2'-yl)-2-ethoxycarbonyl phenyl Sulfonylurea Derivatives [J]. Chem. J. Chinese Universities, 2013, 34(8): 1868.
[10]	QIU Zhao-Lai, LI Wen-Hong, ZHU Hai-Fei, LIU Qian, LI Yuan. Synthesis, Crystal Structure and Antifungal Activities of 3-(CH₂)_nCO₂C₂H₅-1,5-Benzothiazepines [J]. Chem. J. Chinese Universities, 2013, 34(3): 579.
[11]	ZHAO Lian, YUAN Xiang-Guo, ZHAO Jian-Peng, CHEN Hua*, LIU Li, LI Xiao-Liu, CAO Ke-Qiang. Design, Synthesis and Antifungal Activity Against Valsa Mali of the Triamino Substitued Triazines Bearing Aminopyrimidine Group [J]. Chem. J. Chinese Universities, 2011, 32(12): 2795.
[12]	SUN Qing-Yan*, CAO Yong-Bing, XU Jian-Ming, ZHANG Wan-Nian, ZHANG Jun, WU Qiu-Ye, ZHANG Da-Zhi, JIANG Yuan-Ying. Synthesis and Antifungal Activity of Novel Triazole Derivatives [J]. Chem. J. Chinese Universities, 2007, 28(9): 1707.
[13]	LI Ze-Rong, CHEN Shi-Wei, TAN Ning-Xin, CHEN Yu-Zong, LI Xiang-Yuan . Prediction of Antifungal Activity with Support Vector Machine [J]. Chem. J. Chinese Universities, 2005, 26(8): 1522.
[14]	WANG Xiao-Ping, WANG Dao-Quan. Synthesis and Antifungal Activity of N-Substituted-α-oxocyclododecylsulphonamides [J]. Chem. J. Chinese Universities, 1997, 18(6): 889.
[15]	LIAO Ren-An, XIE Qing-Lan, WU Yi-Min. Studies on Organosilicon Compounds with Biological Activity(Ⅻ)─Synthesis of N-Alkyl-N-trimethylsilyl-5-t-butyl-2-furoamides and Their Biological Activity [J]. Chem. J. Chinese Universities, 1994, 15(7): 1017.

Syntheses of (3-Benzyl-4-aroyl-l,2?-triazole-5-yl) (5-phenyI-l, 3,4-oxadiazole-2-yl) Sul fides

PDF (PC)

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments