The Superoxide Dismutase Activity of Binuclear Model Compounds Containing Copper (Ⅱ), Iron(Ⅲ) and Manganese (Ⅱ)

Chem. J. Chinese Universities ›› 1992, Vol. 13 ›› Issue (5): 697.

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The Superoxide Dismutase Activity of Binuclear Model Compounds Containing Copper (Ⅱ), Iron(Ⅲ) and Manganese (Ⅱ)

LIAO Zhan-ru¹, HUANG Yan¹, SHI Ju-en¹, LU Chang-lin²

1. Department of Chemistry, Huazhong Normal University, Wuhan, 430070;
2. Department of Chemistry, Huazhong University of Science and Technology

Received:1991-04-06 Online:1992-05-24 Published:1992-05-24

Abstract

Abstract: We synthesized and characterized a ligand, N,N,N',N'-tetrakis (2'-benzimidazolyl methyl)-1,4-diethylene amino glycol ether (EGTB) and its binuclear complexes containing cop-per(Ⅱ), iron(Ⅲ) and manganese(Ⅱ).An assay of superoxide dismutase (SOD) activity was performed by means of pyrogallol autoxidation.It was found that all model compounds possess excellent SODactivity and they show more than 50% inhibition ratio in the concentration range of 10^-6～10^-7 mol/L of the complexes.

Key words: Superoxide dismutase, Model compound, Assay of activity

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LIAO Zhan-ru, HUANG Yan, SHI Ju-en, LU Chang-lin. The Superoxide Dismutase Activity of Binuclear Model Compounds Containing Copper (Ⅱ), Iron(Ⅲ) and Manganese (Ⅱ)[J]. Chem. J. Chinese Universities, 1992, 13(5): 697.

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The Superoxide Dismutase Activity of Binuclear Model Compounds Containing Copper (Ⅱ), Iron(Ⅲ) and Manganese (Ⅱ)

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