Abstract: In this paper the heparinization of quaternaryly-ammonized poly-p-chloromethyl styrene (QAP-p-CMS) is studied and a method for calculating the average number of ionic bonds between QAP-p-CMS and heparin molecule is put forward. It is shown that both the amount of heparin and the quaternaryly-ammonization extent of P-p-CMS make a great impact on the constitutional and structural aspects of HP-p-CMS. The raise of the amount of heparin or the quaternaryly-ammonization extent of P-p-CMSa ll makes the heparin content of HP-p-CMS increase and the amount of ionic bonds between heparin molecule and QAP-p-CMS decrease gradually. Finally, an explanation for the results of heparinization is suggested.

Key words: Quaternaryly ammonized poly-p-chloromethyl styrene, Heparin, Heparinization