Studies on the Synthesis and Antitumour Activity of γ-(Arylideneamino)propylsilatranes

Abstract

Abstract: Fourteen γ-(arylideneamino)propylsilatranes were synthesized by the condensation of arylaldehydes with γ-aminopropylsilatrane in benzene. The structure of these new compounds were identified by ¹HNMR, IR and UV as well as elemental analysis. Animal screening data show that the inhibition ratios of γ-(3-nitrobenzylideneamino)propylsilatrane, γ-(2-hydroxybenzylideneamino)pro-pylsilatrane, and γ-(2,4-dihydroxybenzylideneamino)propylsilatrane against Erlich ascites cancer in mice are 41.6%, 51.1% and 53.1%, respectively.

Key words: Antitumour activity, Silatrane, γ-Aminopropylsilatrane, Schiff base

TrendMD:

Ding Qizhu, Luo Xuangan, Zhuo Renxi . Studies on the Synthesis and Antitumour Activity of γ-(Arylideneamino)propylsilatranes[J]. Chem. J. Chinese Universities, 1989, 10(4): 369.

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Studies on the Synthesis and Antitumour Activity of γ-(Arylideneamino)propylsilatranes

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