Investigation on Sulfamethazine Molecularly Imprinted Two-dimensional Photonic Crystal Hydrogel Sensor†

doi:10.7503/cjcu20170571

Abstract

Abstract:

A novel sensor for the rapid and label-free detection of sulfamethazine, based on the combination of photonic crystal and molecular imprinting technique, was developed. The molecularly imprinted photonic hydrogel(MIPH) was prepared using sulfamethazine as the template molecule. The results showed that the diameter of Debye ring increased 0.9 cm when the concentration of SM2 changed from 0 to 1×10^-6 mol/L, namely, the lattice spacing decreased 46 nm. When the ratio of crosslinking of MIPH is 10% and the molar ratio of imprinting molecule to functional monomer is 1∶75, the diameter of Debye ring is the largest. In addition, the diameter of Debye ring only increased 0.2, 0.25, 0.3 and 0.4 cm, respectively when the hydrogel immersed in 1×10^-6 mol/L roxithromycin(RM), tetracycline(TE), sulfonisoxazole(SIZ) and sulfadiazine(SDZ) solution, indicating that the MIPH had a high selectivity. The sensor was also tested for simulated water samples and sulfadimethanol veterinary tablets, and all of them had high responsiveness. The application of such a sensor with high selectivity, high sensitivity, and easy operation might offer a new method for rapid real-time detection of Sulfamethazine.

Key words: Sulfamethazine, Molecularly imprinting, Two-dimensional photonic crystal, Hydrogel, Sensor

CLC Number:

O658

TrendMD:

CHEN Xiaojuan, LIU Genqi, REN Chenrui, GAO Minjun, FAN Xiaodong. Investigation on Sulfamethazine Molecularly Imprinted Two-dimensional Photonic Crystal Hydrogel Sensor^†[J]. Chem. J. Chinese Universities, 2018, 39(2): 212.

Figures/Tables 9

Scheme 1 Schematic illustration for the preparation of MIPH

Fig.1 Illustration of Debye diffraction ring measurement(A) and photograph of Debye ring resulting from diffraction of green laser light by MIPH(B)

Fig.2 SEM images of close packed PS 2D arrays(A) and MIPH(B) The insets are the photographs of PS 2D arrays(A) and MIPH(B)

Fig.3 Dependence of the Debye rings diameter of MIPH(a) and NIPH(b) on the SM2 concentration

Fig.4 Dependence of the particle spacing of the MIPH(a) and NIPH(b) on the SM2 concentration

Fig.5 Schematic of MIPH response to SM2

Fig.6 Change of the Debye rings diameter of MIPH vs. the SM2 concentration prepared with different amounts of crosslinking agenta. 10%; b. 15%; c. 5%; d. 20%.

Fig.7 Repeatibility of MIPH response to 1×10-4 mol/L SM2 solutions and then recovered in a pure phosphate buffer after elution

Fig.8 Selectively recognize of MIPH with different concentrations of SM2(a), SDZ(b), SIZ(c), TE(d) and RM(e)

References 30

[1]	Li Y. X., Zhang X. L., Li W., Lu X. F., Liu B., Wang J., Environmental Monitoring and Assessment,2013, 185(3), 2211—2220
[2]	European Commission. Community Procedures for the Establishment of Residue Limits of Pharmacologically Active Substances in Foodstuffs of Animal Origin, (EC)No 470/2009, 2009-12-24
[3]	Ministry of Agriculture of the People’s Republic of China, Maximum Residue Limits for Veterinary Drug in Animal-derived Foods, No.235, 2002-12-24
	(中华人民共和国农业部. 动物性食品中兽药最高残留限量, 中华人民共和国农业部第235号公告, 2002-12-24)
[4]	Pikkemaat M. G., Dijk S. O., Schouten J., Rapallini M., Egmond H. J. V., Food Control, 2008, 19(8), 781—789
[5]	Dmitrienko S. G., Kochuk E.V., Tolmacheva V. V., Apyari V. V., Zolotov Y. A., Food Chemistry, 2015, 188, 51—56
[6]	Ministry of Agriculture of the People’s Republic of China, Detection of Sulfamethazine Residue in Animal-derived Foods by ELISA, No.1025, 2008-04-29
	(中华人民共和国农业部. 动物源食品中磺胺二甲嘧啶残留检测酶联免疫吸附法, 中华人民共和国农业部第1025号公告, 2008-04-29)
[7]	Yan R., Shao M. Y., Ju F. L., Song D. Q., Zhang H. Q., Yu A. M., Chinese J. Anal. Chem., 2013, 41(2), 315—316
	(闫蕊, 邵明媛, 鞠福龙, 宋大千, 张寒琦, 于爱民. 分析化学, 2013,41(2), 315—316)
[8]	Sharma P. S., Dabrowski M., D’Souza F., Kutner W., Trac-Trend. Anal. Chem., 2013, 51(11), 146—157
[9]	Wang H., Zhang K. Q., Sensors,2013, 13(4), 4192—4213
[10]	Ye L., Mosbach K., Chem. Mater., 2008, 20(3), 859—868
[11]	Chen J. I. L., Freymann G. V., Choi S. Y., Kitaev V., Ozin G. A., J. Mater. Chem., 2008, 18(18), 369—373
[12]	Xue Y. F., Liu G. Q., Gao M. J., Chen X. J., Fan X. D., Chinese J. Anal. Chem., 2016, 44(12), 1828—1833
	(薛亚峰, 刘根起, 高敏君, 陈小娟, 范晓东. 分析化学, 2016, 44(12), 1828—1833).
[13]	Yang Z. K., Zhang X. D., Shi D. J., Chen M. Q., Liu S. R., Chem. J. Chinese Universities, 2016, 37(1), 37—42
	(杨兆昆, 张晓栋, 施冬健, 陈明清, 刘士荣. 高等学校化学学报, 2016,37(1), 37—42)
[14]	Sai N., Wu Y. T., Sun Z., Huang G. W., Gao Z. X., Talanta,2015, 144(1), 157—162
[15]	You A. M., Cao Y. H., Cao G. Q., RSC Adv., 2016, 6(87), 83663—83667
[16]	Hou J., Zhang H. C., Yang Q., Li M. Z., Jiang L., Song Y. L., Small,2015, 11(23), 2738—2742
[17]	Lan X. B., Zhao W. B., Wang M. F., Qi W., Su R. X., He Z. M., Chinese J. Anal. Chem., 2015, 43(4), 471—478
	(兰小波, 赵文斌, 王梦凡, 齐崴, 苏荣欣, 何志敏. 分析化学, 2015,43(4), 471—478)
[18]	Ran D., Wang Y., Jia X., Nie C., Anal. Chim. Acta, 2012, 723(8), 45—53
[19]	Griffete N., Frederich H., Maître A., Ravaine S., Chehimi M. M., Mangeney C., Langmuir,2012, 28(1), 1005—1012
[20]	Wang X., Mu Z., Liu R., Pu Y., Yin L., Food Chem., 2013, 141(4), 3947—3953
[21]	Meng L., Meng P. J., Zhang Q. Q., Wang Y. J., Chinese J. Anal. Chem., 2015, 43(4), 495—501
	(孟梁, 孟品佳, 张庆庆, 王彦吉. 分析化学, 2015,43(4), 495—501)
[22]	Zhang R., Liu X. Y., Yu L. P., Chem. Ind. Eng., 2016, 33(3), 39—44
	(张蓉, 刘晓燕, 余莉萍. 化学工业与工程, 2016,33(3), 39—44)
[23]	Gao M. J., Liu G. Q., Xue Y. F., Chen X. J., Shi W. J., Fan X. D., Chinese J. Anal. Chem., 2017, 45(5), 727—733
	(高敏君, 刘根起, 薛亚峰, 陈小娟, 师维江, 范晓东. 分析化学, 2017,45(5), 727—733)
[24]	Tikhonov A., Kornienko N., Zhang J. T., Wang L., Asher S. A., J. Nanophotonics, 2012, 6(1), 3957—3965
[25]	Cai Z., Smith N. L., Zhang J. T., Asher S. A., Anal. Chem., 2015, 87(10), 5013—5025
[26]	Smith N. L., Hong Z., Asher S. A., Analyst,2014, 139(24), 6379—6386
[27]	Reese C. E., Asher S. A., J. Colloid Interface Sci., 2002, 248(1), 41—46
[28]	Zhang J. T., Wang L., Lamont D. N., Velankar S. S., Asher S. A., Angew. Chem. Int. Ed., 2012, 51(25), 6117—6120
[29]	Cai Z., Luck L. A., Punihaole D., Madura J. D., Asher S. A., Chem. Sci., 2016, 7(7), 4557—4562
[30]	Coukouma A. E., Smith N. L., Asher S. A., Analyst,2015, 140(19), 6517—6521