Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology†

doi:10.7503/cjcu20140842

Abstract

Abstract:

Using the potassium persulfate(KPS) as an initiator, through modified reaction of diacetone acrylamide(DAA) and sodium alginate(SA), the amphiphilic SA-PDAA block copolymer was synthesized. By electrospinning the mixture of SA-PDAA and polyvinyl alcohol(PVA) solution, SA-PDAA/PVA electrospun fibers were prepared. The structure and properties of SA-PDAA were characterized by means of Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry(DSC) and fluorescence spectrum. Furthermore. The physical properties of SA-PDAA spinning solution were determined by viscometer, surface tensiometer and electrical conductivity meter, the morphology of SA-PDAAA/PVA electrospun fibers were determined by scanning electron microscopy(SEM). And the drug release studies of SA-PDAAA/PVA electrospun fibers were also investigated. Experimental results showed that DAA had successfully grafted onto the sodium alginate molecular chains. The critical aggregation concentration measured by fluorescence spectrum was reduced to 0.072 g/L, which demonstrated the good amphipathy of SA-PDAA. The morphology of SA-PDAA/PVA electrospun fiber exhibited more uniform size. The drug release properties show that SA-PDAA can effectively slow the drug release rate, thus improving the retarded releasing characteristics of SA-PDAA/PVA electrospun fibers.

Key words: Modified sodium alginate, Polyvinyl alcohol, Electrospinning, Nanofiber, Diacetone acrylamide

TrendMD:

GAO Pengbo, FENG Yuhong, LI Jiacheng, YAN Huiqiong, HUANG Junhao, WU Tiantian, HUANG Wenhong. Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology^†[J]. Chem. J. Chinese Universities, 2015, 36(4): 799.

Figures/Tables 12

Fig.1 FTIR spectra of SA(a) and SA-PDAA(b)

Fig.2 DSC curves of SA(a) and SA-PDAA(b)

Fig.3 Variation of I1/I3 with the solutions concentration of SA(a) and SA-PDAA(b)

Fig.4 Variation of viscosity curves with the volume fractions of the PVA solution a. SA/PVA; b. SA-PDAA/PVA.

Fig.5 Variation of surface tension curves with the volume fractions of the PVA solution Error bars represent the standard deviation of ten replicates. a. SA/PVA; b. SA-PDAA/PVA.

Fig.6 Variation of conductivity curves with the volume fractions of the PVA solution a. SA/PVA; b. SA-PDAA/PVA.

Fig.7 SEM images of SA/PVA electrospun fibers V(SA):V(PVA): (A) 20:80; (B) 30:70; (C) 40:60; (D) 50:50; (E) 60:40. The insets show SEM images of nanofibers at a higher magnification.

Fig.8 SEM images of SA-PDAA/PVA electrospun fibers V(SA-PDAA):V(PVA): (A) 20:80; (B) 30:70; (C) 40:60; (D) 50:50; (E) 60:40. The insets show SEM images of nanofibers at a higher magnification.

Fig.9 SEM images of the blend nanofibers with drug (A) The nanofibers of SA/PVA with drug; (B) the nanofibers of SA-PDAA/PVA with drug. The insets show SEM images of nanofibers at a higher magnification.

Fig.10 Release of acetamiprid from the nanofibers a. Nanofibers of SA/PVA; b. nanofibers of SA-PDAA/PVA. Error bars represent the standard deviation of three replicates.

Table 1 Data fitting results of the different formulations of acetamiprid release

Formulation	K/h^-ⁿ	n	R²	Mechanism
SA/PVA	3.6171±0.0004	0.7804±0.0084	0.991	Non-Fickian
SA-PDAA/PVA	1.9270±0.0002	0.9540±0.0091	0.990	Non-Fickian

Fig.11 Mechanism of molecular chain structure entanglements in SA solution, SA-PDAA solution and SA-PDAA spinning solution

References 50

[1]	Braccini I., Pérez S., Biomacromolecules,2001, 2(4), 1089—1096
[2]	Kumbar S. G., Soppimath K. S., Aminabhavi T. M., Journal of Applied Polymer Science,2003, 87(9), 1525—1536
[3]	George M., Abraham T. E., Journal of Controlled Release,2006, 114(1), 1—14
[4]	Hua S. B., Ma H. Z., Li X., Yang H. X., Wang A. Q., International Journal of Biological Macromolecules,2010, 46(5), 517—523
[5]	Correia T. R., Antunes B. P., Castilho P. H., Nunes J. C., Pessoa M. T., Escobar I. C., Queiroz J. A., Correia I. J., Morão A. M., Separation and Purification Technology,2013, 28(112), 20—25
[6]	Doshi J., Reneker D. H., Journal of Electrostatics,1995, 35(223), 151—160
[7]	Wang R., Mo X., Wang X., Journal of Textile Research,2014, 35(02), 145—152
	(王锐, 莫小慧, 王晓东. 纺织学报, 2014, 35(02), 145—152)
[8]	Fan Y. N, Cai Z. J., Zhao K. Y., Polymer Bulletin,2013, 25(11), 70—75
	(樊亚男, 蔡志江, 赵孔银. 高分子通报, 2013, 25(11), 70—75)
[9]	Mackie W., Perez S., Rizzo R., Taravel F., Vignon M., International Journal of Biological Macromolecules,1983, 5(6), 329—341
[10]	Reneker D. H., Yarin A. L., Fong H., Koombhongse S., Journal of Applied Physics,2000, 87(9), 4531—4547
[11]	Nie H. R., He A. H., Wu W. L., Zheng J. F., Xu S. S., Lia J. X., Hana C. C., Polymer,2009, 50(20), 4926—4934
[12]	Lee Y. J., Shin D. S., Kwon O. W., Park W. H., Choi H. G., Lee Y. R., Han S. S., Noh S. K., Lyoo W. S., Journal of Applied Polymer Science,2007, 106(2), 1337—1342
[13]	Lu J. W., Zhu Y. L., Guo Z. X., Ping H., Jian Y., Polymer,2006, 47(23), 8026—8031
[14]	Wei S. B., Zhang S. X., Li J. C., Feng Y. H., Zhang X. L., Li K., Huang J. H., China Surfactant Detergent and Cosmetics,2014, 43(6), 301—305, 311
	(魏思宝, 张世鑫, 李嘉诚, 冯玉红, 张学良, 李可, 黄俊浩. 日用化学工业, 2014, 43(6), 301—305, 311)
[15]	Pan M. D., Li J. C., Lin Q., Wang X. H., Wang L. H., China Pharmaceuticals,2008, 17(19), 3—5
	(盘茂东, 李嘉诚, 林强, 王向辉, 汪莉华. 中国药业, 2008, 17(19), 3—5)
[16]	Rösler A., Vandermeulen G. W. M., Klok H. A., Advanced Drug Delivery Reviews,2012, 25(64), 270—279
[17]	Kulkarni R. V., Setty C. M., Sa B., Journal of Applied Polymer Science,2010, 115(2), 1180—1188
[18]	Yan H. Q., Li J. C., Feng Y. H., Hu W. T., Niu D., Lin Q., Fine Chemicals,2013, 30(2), 975—980, 984
	(颜慧琼, 李嘉诚, 冯玉红, 胡文涛, 牛迪, 林强. 精细化工, 2013, 30(2), 975—980, 984)
[19]	Xu G. Z., Liu X. D., Yu W. T., Ding D. H., Ma X. J., Materials Review,2013, 26(7), 76—80
	(许冠哲, 刘袖洞, 于炜婷, 丁东慧, 马小军. 材料导报, 2013, 26(7), 76—80)
[20]	Yang L., Zhang L. M., Carbohydrate Polymers,2009, 76(3), 349—361
[21]	Yadav M., Mishra D. K., Sand A., Behari K., Carbohydrate Polymers,2011, 84(1), 83—89
[22]	Xu G. Z., Liu X. D., Wang B., Yu W. T., Ding D. H., Ma X. J., Chemical Research and Application,2013, 25(8), 1097—1101
	(许冠哲, 刘袖洞, 王冰, 于炜婷, 丁东慧, 马小军. 化学研究与应用, 2013, 25(8), 1097—1101)
[23]	Mandal S., Basu S. K., Sa B., Carbohydrate Polymers,2010, 82(3), 867—873
[24]	Hashimoto T., Suzuki Y., Tanihara M., Kakimaruc Y., Suzukia K., Biomaterials,2004, 25(7), 1407—1414
[25]	Pawar S. N., Edgar K. J., Biomaterials,2012, 33(11), 3279—3305
[26]	Yang J. S., Xie Y. J., He W., Carbohydrate Polymers,2011, 84(1), 33—39
[27]	Zohuriaan-Mehr M. J., Pourjavadi A., Polymers for Advanced Technologies,2003, 14(7), 508—516
[28]	Işıklan N., Inal M., Yigitoglu M., Journal of Applied Polymer Science, 2008, 110(1), 481—493
[29]	Liu Y., Li Y., Yang L., Liu Y., Bai L., Iranian Polymer Journal,2005, 14(5), 457
[30]	Islam M. S., Karim M. R., Colloids and Surfaces A: Physicochemical and Engineering Aspects,2010, 366(1), 135—140
[31]	Yan H. Q., Li J. C., Feng Y. H., Hu W. T., Liu R. L., Lin Q., Chem. J. Chinese Universities,2013, 34(9), 2164—2170
	(颜慧琼, 李嘉诚, 冯玉红, 胡文涛, 刘若林, 林强. 高等学校化学学报, 2013, 34(9), 2164—2170)
[32]	Wang C., Lu X.F., Organic Functional Nanomaterials, Science Press, Beijing, 2011, 34—35
	(王策, 卢晓峰. 有机纳米功能材料. 北京: 科学出版社, 2011, 34—35)
[33]	Nie H., He A., Zheng J., Xu S., Li J., Han C. C., Biomacromolecules,2008, 9(5), 1362—1365
[34]	Saquing C. D., Tang C., Monian B., Bonino C. A., Manasco J. L., Alsberg E., Khan S. A., Industrial and Engineering Chemistry Research,2013, 52(26), 8692—8704
[35]	Safi S., Morshed M., Hosseini R. S. A., Ghiaci M., Journal of Applied Polymer Science,2007, 104(5), 3245—3255
[36]	Caykara T., Demirci S., Eroglu M. S., Güven O., Polymer, 2005, 46(24), 10750—10757
[37]	Ding B., Jian Y.Y., Electrospinning and Nanofibers, China Textile Press, Beijing, 2011, 39—40
	(丁彬, 俞建勇. 静电纺丝与纳米纤维, 北京: 中国纺织出版社, 2011, 39—40)
[38]	Shen W., Hsieh Y. L., Carbohydrate Polymers,2014, 102(4), 893—900
[39]	Shalumon K. T., Anulekha K. H., Nair S. V., Chennazhi K. P., Jayakumar R., International Journal of Biological Macromolecules,2011, 49(3), 247—254
[40]	Qi D. Y., Liu Y. B., Song G. W., China Synthetic Fiber Industry,2014, 37(1), 25—28, 32
	(漆东岳, 刘延波, 宋国文. 合成纤维工业, 2014, 2014, 37(1), 25—28, 32)
[41]	Jo E., Lee S., Kim K. T., Won Y. S., Kim H., Cho1 E. C., Jeong U., Advanced Materials,2009, 21(9), 968—972
[42]	Taepaiboon P., Rungsardthong U., Supaphol P., Nanotechnology,2006, 17(9), 2317
[43]	Zeng J., Yang L., Liang Q., Zhang X., Guan H., Xua X Chen X., Jing X., Journal of Controlled Release,2005, 105(1), 43—51
[44]	Li T. T., Liu C., Zhang Z. M., An L. B., Yang C. H., Chem. J. Chinese Universities,2014, 35(2), 389—395
	(李婷婷, 刘策, 张志明, 安立宝, 杨翠环. 高等学校化学学报, 2014, 35(2), 389—395)
[45]	Sanders E. H., Kloefkorn R., Bowlin G. L., Simpson D. G., Wnek G. E., Macromolecules,2003, 36(11), 3803—3805
[46]	Xu X., Chen X., Liu A., Hong Z., Jinga X., European Polymer Journal,2007, 43(8), 3187—3196
[47]	Siepmann J., Kranz H., Peppas N. A., Bodmeier R., International Journal of Pharmaceutics,2000, 201(2), 151—164
[48]	Ritger P. L., Peppas N. A., Journal of Controlled Release,1987, 5(1), 23—36
[49]	Dai Y., Niu J., Liu J., Yin L., Xu J., Bioresource Technology,2010, 101(23), 8942—8947
[50]	Jannesari M., Varshosaz J., Morshed M., Zamani M., International Journal of Nanomedicine,2011, 5(6), 993—1003