CJCU

Chem. J. Chinese Universities ›› 2013, Vol. 34 ›› Issue (1): 236.doi: 10.7503/cjcu20120294

• Polymer Chemistry • Previous Articles     Next Articles

Preparation and Bioactivities of DhHP-6-loaded Biodegradable Polymeric Microspheres

ZHAO Tian-Yi1, ZHAO Ji-Peng1, LEI Li-Yan1, CHEN Xiao-Guang1, WANG Li-Cheng2, CHEN Xue-Si3, WANG Li-Ping1   

  1. 1. Academy of Life Science, Jilin University, Changchun 130012, China;
    2. College of Chemistry, Jilin University, Changchun 130012, China;
    3. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China
  • Received:2012-04-01 Published:2012-12-31

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Abstract:

Two polyester microspheres were prepared by a water-in-oil-in-water(W1/O/W2) double emulsion solvent evaporation and deuterohaemin-β-AHTVEK(DhHP-6) was encapsulated to the polyester microspheres by a technique with good sphericity and high efficiency. The in vitro release profiles and in vivo biological activity of the polyester microspheres were evaluated by scanning electron microscope(SEM), in vitro release, high performance liquid(HPLC), enzyme activity detection and animal experiments. The data suggested that the drug-loaded polyester microspheres were spherical morphology with narrow size distribution, and had high entrapment capacity with great in vitro release profiles. Furthermore, the drug-loaded polyester microspheres had protective effects on cell injury induced by hydrogen peroxide and cerebral ischemic injury in mice.

Key words: Drug-loaded microsphere, Deuterohaemin-β-AHTVEK(DhHP-6), Polylactic-co-glycolic acid(PLGA), Polylactic-co-glycolic acid/PEG, Sustained-release

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