高等学校化学学报 ›› 2002, Vol. 23 ›› Issue (7): 1417.

• 研究论文 • 上一篇    下一篇

海藻酸钠-壳聚糖微胶囊膜强度的研究

刘群, 薛伟明, 于炜婷, 刘袖洞, 严若媛, 李金云, 马小军   

  1. 中国科学院大连化学物理研究所, 大连 116023
  • 收稿日期:2001-04-29 出版日期:2002-07-24 发布日期:2002-07-24
  • 通讯作者: 马小军(1958年生),男,研究员,博士生导师,从事生物医用材料工程学研究.E-mail:maxj@dicp.ac.cn E-mail:maxj@dicp.ac.cn
  • 基金资助:

    国家自然科学基金项目(批准号:29906011)

Studies on the Membrane Strength of Alginate/Chitosan Microcapsule Prepared by Emulsification/Internal Gelation Method

LIU Qun, XUE Wei-Ming, YU Wei-Ting, LIU Xiu-Dong, YAN Ruo-Yuan, LI Jin-Yun, MA Xiao-Jun   

  1. Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, 116023, China
  • Received:2001-04-29 Online:2002-07-24 Published:2002-07-24

摘要: 以乳化/内部凝胶化法制备了海藻酸钠-壳聚糖微胶囊,重点考察了成膜反应过程中影响微胶囊膜强度的几个主要参数,实验发现,壳聚糖分子量低于100000,成膜反应时间高于15min,壳聚糖溶液pH值在6.0左右时制备的微胶囊膜强度较高.初步探讨了海藻酸钠与壳聚糖两种高分子发生聚电解质络合反应的机制.

关键词: 海藻酸钠, 壳聚糖, 微胶囊, 乳化, 内部凝胶化

Abstract: The alginate/chitosan microcapsule was prepared by emulsification/internal gelation method. It was found that the membrane strength was significantly affected by the molecular weight of chitosan, reaction time of these two polymers and the pHvalue of chitosan solution. When the molecular weight of chitosan was lower than 0.1 million, reaction time was higher than 15 min, pHof chitosan solution was about 6.0, then the most strongest membrane was obtained. At the same time the principle of the reaction of polyelectrolyte complexation was investigated.

Key words: Alginate, Chitosan, Microcapsule, Emulsification, Internal gelation

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