高等学校化学学报

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胆酸钠与支撑磷脂双层膜作用的电化学研究

王建国, 杨薇薇, 江黎丽, 吕慧, 孙巧花, 马勇, 姜玉春, 臧树良   

  1. 辽宁大学化学学院, 沈阳 110036
  • 收稿日期:2006-06-26 修回日期:1900-01-01 出版日期:2007-05-10 发布日期:2007-05-10
  • 通讯作者: 王建国

Electrochemical Study on the Interaction of Sodium Cholate with a Supported Lipid Bilayer Membrane

WANG Jian-Guo*, YANG Wei-Wei, JIANG Li-Li, LÜ Hui, SUN Qiao-Hua, MA Yong, JIANG Yu-Chun, ZANG Shu-Liang   

  1. College of Chemistry, Liaoning University, Shenyang 110036, China
  • Received:2006-06-26 Revised:1900-01-01 Online:2007-05-10 Published:2007-05-10
  • Contact: WANG Jian-Guo

摘要: 采用电化学方法研究胆酸钠(NaC)与s-BLM的相互作用, 并结合实验结果对NaC与s-BLM的作用机理进行了讨论.

关键词: 支撑磷脂双层膜, 胆酸钠, 循环伏安, 交流阻抗

Abstract: The supported bilayer lipid membrane(s-BLM) was served as a biomembrane model. The interaction between sodium cholate(NaC) and s-BLM was investigated by cyclic voltammetry and alternating current(AC) impedance spectroscopy. The following conclusions were obtained: NaC can decrease the orderliness of lecithin molecule arrangement and induce pores or defects on s-BLM and the interaction between them depends on time, concentration and cholesterol. In addition, the defective s-BLM after interaction can be self-repaired in 0.1 mol/L KCl solution, which indicates that the interaction is reversible. Moreover, a possible mechanism of the interaction was proposed finally.

Key words: Supported lipid bilayer membrane, Sodium cholate, Cyclic voltammetry, Alternating current impedance

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