高等学校化学学报

高等学校化学学报

• 研究简报 • 上一篇    

新型仿生聚合物胶束用于纳米药物载体的研究

徐建平, 陈伟东, 计剑, 沈家骢   

  1. 浙江大学高分子科学与工程学系, 教育部高分子合成与功能构造重点实验室, 杭州 310027
  • 收稿日期:2006-08-10 修回日期:1900-01-01 出版日期:2007-02-10 发布日期:2007-02-10
  • 通讯作者: 计剑

Novel Biomimetic Polymeric Micelles for Drug Delivery

XU Jian-Ping, CHEN Wei-Dong, JI Jian, SHEN Jia-Cong   

  1. Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:2006-08-10 Revised:1900-01-01 Online:2007-02-10 Published:2007-02-10
  • Contact: JI Jian

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摘要： 对两亲性聚合物进行设计和优化, 从细胞膜仿生的设计出发, 利用原子转移自由基聚合, 制备了一种以胆固醇为疏水段、以仿细胞膜磷酸胆碱基聚合物为亲水段的两亲性分子CMPC. 在对其溶液胶束自组装行为进行探索的基础上, 以水包油(O/W)溶剂挥发法制备了包含抗癌药物阿霉素(ADR)的纳米抗癌药物载体, 通过体外细胞培养, 研究了仿细胞膜两亲分子的细胞相容性, 并对抗癌纳米药物载体抗肿瘤细胞的药效进行了初步研究.

关键词: 聚合物胶束, 细胞膜仿生, 药物缓释, 生物相容性, 磷酸胆碱

Abstract: Novel amphiphilic polymers, cholesterol-end-capped poly(2-methacryloyloxyethyl phosphorylcholine)(CMPC) was specially designed as the drug delivery systems. Cytotoxicity of this novel amphiphiles was not observed as indicated by cell culture. Anti-cancer drug adriamycin(ADR) was incorporated into the micelles by oil-in-water method. The release of ADR from the nanosphere continued over 7 d. The drug-loaded micelles could effectively restrain the growth of cancer cell. These results suggest that the drug loaded nanoparticles could be a good candidate for injectable drug delivery carrier.

Key words: Polymeric micelles, Biomimetic of cell membrane, Drug sustained release, Biocompatibility, Phosphorylcholine

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