高等学校化学学报 ›› 2018, Vol. 39 ›› Issue (9): 1881.doi: 10.7503/cjcu20180357

• 研究论文:无机化学 • 上一篇    下一篇

聚乙烯亚胺修饰BaGdF5纳米粒子的制备及CT/MR双模成像性能

刘建华1,2, 施展1, 李波2, 张天琪2, 崔凤至2, 袁庆海2()   

  1. 1. 吉林大学无机合成与制备化学国家重点实验室, 化学学院, 长春 130012
    2. 吉林大学第二医院, 长春 130041
  • 收稿日期:2018-05-11 出版日期:2018-09-07 发布日期:2018-08-03
  • 作者简介:

    联系人简介: 袁庆海, 男, 博士, 教授, 博士生导师, 主要从事分子影像学方面的研究. E-mail: yuanqinghai123@sina.com

  • 基金资助:
    国家自然科学基金(批准号: 81571737)、 吉林省自然科学基金(批准号: 20180101119JC)和吉林省卫计委青年基金(批准号: 2017Q012)资助.

Synthesis of PEI-conjugated BaGdF5 Nanoparticle for in vivo Dual-modal MR and CT Imaging

LIU Jianhua1,2, SHI Zhan1, LI Bo2, ZHANG Tianqi2, CUI Fengzhi2, YUAN Qinghai2,*()   

  1. 1. State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130012, China
    2. The Second Hospital of Jilin University, Changchun 130041, China
  • Received:2018-05-11 Online:2018-09-07 Published:2018-08-03
  • Contact: YUAN Qinghai E-mail:yuanqinghai123@sina.com
  • Supported by:
    † Supported by the National Natural Science Foundation of China(No. 81571737), the Natural Science Foundation of Jilin Province, China(No. 20180101119JC) and the Youth Training Foundation by the Health and Family Planning Commission of Jilin Province, China(No. 2017Q012).

摘要:

通过微波辅助的溶剂热法制备了聚乙烯亚胺修饰BaGdF5纳米粒子, 并对其进行了表征、 毒性评估、 计算机X射线断层扫描(CT)成像及磁共振(MR)成像分析. 透射电子显微镜(TEM)观测结果表明, 该纳米粒子呈球形, 表面光滑, 分布均匀, 粒径约30 nm. MTT结果表明, 该纳米粒子具有较低的细胞毒性; 小鼠各器官的组织病理学结果表明, 该纳米粒子具有较低的体内毒性; 体外成像结果表明, 该纳米粒子具有较好的CT成像及T1加权的MR成像能力; 小鼠体内成像结果表明, 该纳米粒子具有应用于肝脏双模态成像的潜力.

关键词: CT成像, MR成像, 纳米粒子, 造影剂

Abstract:

PEI-conjugated BaGdF5 nanoparticles were synthesized via a one-pot facile but efficient microwave-assisted polyol process. Transmission electron microscopy(TEM), X-ray diffraction(XRD), FTIR spectroscopy, cytotoxicity test, CT imaging and MR imaging were used to characterize these well-prepared nanoparticles. TEM images indicated that these nanoparticles held an average diameter of 30 nm with uniform spherical character and relatively smooth surface. MTT result indicated these nanoparticles showed a very low cytotoxicity. Both in vitro and in vivo imaging results demonstrated that these nanoparticles exhibited excellent dual-modal MR and CT imaging capabilities, indicating their potential applications in further clinical areas.

Key words: CT imaging, MR imaging, Nanoparticles, Contrast agent

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