高等学校化学学报 ›› 2016, Vol. 37 ›› Issue (9): 1629-1635.doi: 10.7503/cjcu20160292

• 有机化学 • 上一篇    下一篇

纳米TiO2催化一锅法合成喹唑啉酮并酞嗪酮及3-酰胺基异吲哚酮并喹唑啉酮类化合物

张金1,2, 刘佳1, 马养民1,2(), 杨秀芳1,2, 程佩1, 范超1, 卢萍1   

  1. 1. 陕西科技大学化学与化工学院, 西安 710021
    2. 教育部轻化工助剂化学与技术重点实验室, 西安 710021
  • 收稿日期:2016-04-29 出版日期:2016-09-10 发布日期:2016-08-18
  • 作者简介:联系人简介: 马养民, 男, 博士, 教授, 博士生导师, 主要从事天然产物提取、 鉴定及合成研究. E-mail:mym63@sina.com
  • 基金资助:
    陕西省自然科学基础研究计划项目(批准号: 2014JQ2064)、 陕西省教育厅重点实验室项目(批准号: 15JS012)和陕西科技大学博士科研启动基金(批准号: BJ12-26)资助

TiO2 Nanoparticles-catalyzed One-pot Synthesis of Quinazolino[2,1-b]phthalazin-8-one and 3-Acylamino Isoindolo[2,1-a]quinazoline Derivatives

ZHANG Jin1,2, LIU Jia1, MA Yangmin1,2,*(), YANG Xiufang1,2, CHENG Pei1, FAN Chao1, LU Ping1   

  1. 1. College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China
    2. Key Laboratory of Auxiliary Chemistry & Technology for Chemical Industry, Ministry of Education, Xi’an 710021, China
  • Received:2016-04-29 Online:2016-09-10 Published:2016-08-18
  • Contact: MA Yangmin E-mail:mym63@sina.com
  • Supported by:
    † Supported by the Natural Science Basic Research Plan in Shaanxi Province of China(No.2014JQ2064), the Scientific Research Project Item for Key Laboratory of Shaanxi Province Education Department, China(No.15JS012) and the Foundation for Young Scholars of Shaanxi University of Science & Technology, China(No.BJ12-26)

摘要:

以纳米TiO2为催化剂, 靛红酸酐、 2-甲酰基苯甲酸、 不同芳香肼或酰肼类化合物为原料, 在乙醇/水溶液为溶剂的条件下一锅法合成, 高产率得到6个喹唑啉酮并酞嗪酮类化合物及10个3-酰胺基取代的异吲哚酮并喹唑啉酮类化合物. 该方法简洁高效, 反应条件温和, 为喹唑啉酮并杂环类化合物的合成提供了一条新途径.

关键词: 纳米TiO2, 一锅法, 喹唑啉酮并酞嗪酮, 3-酰胺基异吲哚酮并喹唑啉酮

Abstract:

An efficient and simple one-pot method was developed for the synthesis of two kinds of N-fused quinazolinone derivatives using nano TiO2 particles as catalyst from isatoic anhydride, 2-carboxy benzaldehyde, hydrazides or aromatic hydrazines. Six quinazolino[2,1-b]phthalazin-8-ones and ten 3-acylamino isoindolo[2,1-a]quinazolines were obtained in excellent yields, and the reaction refluxed in aqueous ethanol were environmentally friendly. Attractive features of this methodology were its versatility, mild condition and high efficiency in creating two different structures in a single operation.

Key words: TiO2 Nanoparticles, One-pot reaction, Quinazolino[2, 1-b]phthalazin-8-one, 3-Acylamino isoindolo[2, 1-a]quinazoline