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PLGA/明胶共混体系的静电纺丝研究

赵瑾, 赵玉平, 张伟, 袁晓燕   

  1. 天津大学材料科学与工程学院, 天津市材料复合与功能化重点实验室, 天津 300072
  • 收稿日期:2008-07-17 修回日期:1900-01-01 出版日期:2009-02-10 发布日期:2009-02-10
  • 通讯作者: 赵瑾

Electrospinning of PLGA/Gt Blend System

ZHAO Jin*, ZHAO Yu-Ping, ZHANG Wei, YUAN Xiao-Yan   

  1. School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials,Tianjin University, Tianjin 300072, China
  • Received:2008-07-17 Revised:1900-01-01 Online:2009-02-10 Published:2009-02-10
  • Contact: ZHAO Jin

摘要: 采用静电纺丝技术制备了聚乳酸乙醇酸(PLGA)/明胶(Gt)的复合超细纤维, 考察了溶液浓度、电压及流速对纤维形貌的影响. 研究了不同明胶比例的纤维膜的微观形貌和干湿态的力学性能. 结果表明, 在溶液浓度0.12 g/mL, 电压7.5 kV, 流速0.8 mL/h条件下, 所得PLGA/Gt复合纤维直径较小, 粗细较均匀且缺陷少. 含有明胶的复合纤维直径远小于PLGA单纺纤维直径, 明胶的加入降低了膜的拉伸强度和断裂伸长率, 提高了膜的亲水性. 经PBS浸泡后, 复合膜的弹性得到加强. 明胶质量分数为5%和10%时, 纤维直径分布较窄, 当明胶的质量分数增加至15%时, 纤维的直径分布变宽.

关键词: 聚乳酸乙醇酸, 明胶, 静电纺丝, 复合纤维, 形貌, 力学性能

Abstract: Poly(lactic-co-glycolic acid)/gelatin ultrafine composite fibers were fabricated via electrospinning. The effects of solution concentration, electric voltage and flow rate on the morphology of fibers were investigated. Also the morphology and mechanical properties of fiber membranes with different mass fraction of gelatin were studied. Results show ultrafine PLGA/gelatin fibers with narrow diameter distribution and little defect are obtained when solution concentration is 0.12 g/mL, voltage is 7.5 kV and flow rate is 0.8 mL/h. Compared with PLGA fibers, the diameter of PLGA/gelatin fibers reduced greatly. Addition of gelatin decreased the tensile strength and elongation of the membrane while increased the hydrophilicity. After immersing in PBS solution, the elasticity of PLGA/gelatin membranes increased. When mass fraction of gelatin was 5% and 10%, the diameter distribution was narrow. However, when it reached 15%, the distribution broadened.

Key words: Poly(lactic-co-glycolic acid), Gelatin, Electrospinning, Composite fibers, Morphology, Mechanical property

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