改性海藻酸钠聚集行为对电纺纳米纤维形貌的影响

doi:10.7503/cjcu20140842

高等学校化学学报 ›› 2015, Vol. 36 ›› Issue (4): 799.doi: 10.7503/cjcu20140842

改性海藻酸钠聚集行为对电纺纳米纤维形貌的影响

高鹏博¹, 冯玉红¹(), 李嘉诚¹(), 颜慧琼², 黄俊浩¹, 武田田¹, 黄文红¹

1. 海南大学材料与化工学院, 海口 570228
2. 海南师范大学化学化工学院, 海口 571158

收稿日期:2014-09-16 出版日期:2015-04-10 发布日期:2015-03-19
作者简介:联系人简介: 冯玉红, 女, 博士, 教授, 主要从事纤维素的改性和生物材料研究. E-mail: ljcfyh@263.net. 李嘉诚, 男, 博士, 教授, 主要从事胶体与界面化学研究. E-mail: lijiacheng@hainu.edu.cn
基金资助:
国家自然科学基金(批准号: 21366010)、海南省重点科技计划(批准号: ZDXM2014037, ZDXM20120003)、海口市重点科技计划项目(批准号: 2014055)、海南省自然科学基金(批准号: 214017)和海南省水环境污染治理与资源化重点实验室开放基金资助

Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology^†

GAO Pengbo¹, FENG Yuhong^1,^*(), LI Jiacheng^1,^*(), YAN Huiqiong², HUANG Junhao¹, WU Tiantian¹, HUANG Wenhong¹

1. College of Materials and Chemical Engineering, Hainan University, Haikou 570228, China
2. College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China

Received:2014-09-16 Online:2015-04-10 Published:2015-03-19
Contact: FENG Yuhong,LI Jiacheng E-mail:ljcfyh@263.net;lijiacheng@hainu.edu.cn
Supported by:
† Supported by the National Natural Science Foundation of China(No.21366010), the Focus Plan of Hainan Province Science and Technology, China(No.ZDXM2014037, ZDXM20120003), the Science and Technology Project of Haikou, China(No.2014055), the Natural Science Foundation of Hainan, China(No.214017), the Open Fund of Hainan Province Water Environmental Pollution Control, China and Resource Reuse Key Laboratory, China

摘要/Abstract

摘要：

以过硫酸钾(KPS)为引发剂, 采用双丙酮丙烯酰胺(DAA)对海藻酸钠(SA)进行改性, 制备了海藻酸钠-聚双丙酮丙烯酰胺两亲性共聚物(SA-PDAA). 将SA-PDAA与聚乙烯醇(PVA)复配, 并进行静电纺丝, 制得SA-PDAA/PVA电纺纳米纤维. 通过红外光谱、差示扫描量热和荧光光谱表征了SA-PDAA的结构和性能, 通过黏度仪、表面张力仪和电导率仪测试了SA-PDAA纺丝液的物理性能, 用扫描电子显微镜表征了SA-PDAA/PVA电纺纳米纤维的形貌, 考察了SA-PDAA/PVA电纺纳米纤维的释药性能. 结果表明, DAA接枝到SA分子链上, SA-PDAA的临界聚集浓度为0.072 g/L, SA-PDAA具有良好的两亲性, SA-PDAA/PVA电纺纳米纤维具有均一的形貌. 改性后的SA可以有效地减缓药物释放速度, 提高SA-PDAA/PVA电纺纳米纤维的缓释性能.

关键词: 改性海藻酸钠, 聚乙烯醇, 静电纺丝, 纳米纤维, 双丙酮丙烯酰胺

Abstract:

Using the potassium persulfate(KPS) as an initiator, through modified reaction of diacetone acrylamide(DAA) and sodium alginate(SA), the amphiphilic SA-PDAA block copolymer was synthesized. By electrospinning the mixture of SA-PDAA and polyvinyl alcohol(PVA) solution, SA-PDAA/PVA electrospun fibers were prepared. The structure and properties of SA-PDAA were characterized by means of Fourier transform infrared spectroscopy(FTIR), differential scanning calorimetry(DSC) and fluorescence spectrum. Furthermore. The physical properties of SA-PDAA spinning solution were determined by viscometer, surface tensiometer and electrical conductivity meter, the morphology of SA-PDAAA/PVA electrospun fibers were determined by scanning electron microscopy(SEM). And the drug release studies of SA-PDAAA/PVA electrospun fibers were also investigated. Experimental results showed that DAA had successfully grafted onto the sodium alginate molecular chains. The critical aggregation concentration measured by fluorescence spectrum was reduced to 0.072 g/L, which demonstrated the good amphipathy of SA-PDAA. The morphology of SA-PDAA/PVA electrospun fiber exhibited more uniform size. The drug release properties show that SA-PDAA can effectively slow the drug release rate, thus improving the retarded releasing characteristics of SA-PDAA/PVA electrospun fibers.

Key words: Modified sodium alginate, Polyvinyl alcohol, Electrospinning, Nanofiber, Diacetone acrylamide

TrendMD:

高鹏博, 冯玉红, 李嘉诚, 颜慧琼, 黄俊浩, 武田田, 黄文红. 改性海藻酸钠聚集行为对电纺纳米纤维形貌的影响. 高等学校化学学报, 2015, 36(4): 799.

GAO Pengbo, FENG Yuhong, LI Jiacheng, YAN Huiqiong, HUANG Junhao, WU Tiantian, HUANG Wenhong. Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology^†. Chem. J. Chinese Universities, 2015, 36(4): 799.

图/表 12

Fig.1 FTIR spectra of SA(a) and SA-PDAA(b)

Fig.2 DSC curves of SA(a) and SA-PDAA(b)

Fig.3 Variation of I1/I3 with the solutions concentration of SA(a) and SA-PDAA(b)

Fig.4 Variation of viscosity curves with the volume fractions of the PVA solution a. SA/PVA; b. SA-PDAA/PVA.

Fig.5 Variation of surface tension curves with the volume fractions of the PVA solution Error bars represent the standard deviation of ten replicates. a. SA/PVA; b. SA-PDAA/PVA.

Fig.6 Variation of conductivity curves with the volume fractions of the PVA solution a. SA/PVA; b. SA-PDAA/PVA.

Fig.7 SEM images of SA/PVA electrospun fibers V(SA):V(PVA): (A) 20:80; (B) 30:70; (C) 40:60; (D) 50:50; (E) 60:40. The insets show SEM images of nanofibers at a higher magnification.

Fig.8 SEM images of SA-PDAA/PVA electrospun fibers V(SA-PDAA):V(PVA): (A) 20:80; (B) 30:70; (C) 40:60; (D) 50:50; (E) 60:40. The insets show SEM images of nanofibers at a higher magnification.

Fig.9 SEM images of the blend nanofibers with drug (A) The nanofibers of SA/PVA with drug; (B) the nanofibers of SA-PDAA/PVA with drug. The insets show SEM images of nanofibers at a higher magnification.

Fig.10 Release of acetamiprid from the nanofibers a. Nanofibers of SA/PVA; b. nanofibers of SA-PDAA/PVA. Error bars represent the standard deviation of three replicates.

Table 1 Data fitting results of the different formulations of acetamiprid release

Formulation	K/h^-ⁿ	n	R²	Mechanism
SA/PVA	3.6171±0.0004	0.7804±0.0084	0.991	Non-Fickian
SA-PDAA/PVA	1.9270±0.0002	0.9540±0.0091	0.990	Non-Fickian

Fig.11 Mechanism of molecular chain structure entanglements in SA solution, SA-PDAA solution and SA-PDAA spinning solution

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改性海藻酸钠聚集行为对电纺纳米纤维形貌的影响

Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology^†

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改性海藻酸钠聚集行为对电纺纳米纤维形貌的影响

Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology†

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Effect of Modified Sodium Alginate Aggregation Behavior on Electrospun Nanofiber Morphology^†