高等学校化学学报 ›› 2013, Vol. 34 ›› Issue (9): 2120.doi: 10.7503/cjcu20121141

• 有机化学 • 上一篇    下一篇

3-(2-羟基-4,6-二甲氧基苯基)-5-芳基异噁唑啉的合成及抑菌活性

江玉亮, 韩巧荣, 周文龙, 徐助雄, 王炳祥   

  1. 江苏省生物功能材料重点实验室, 江苏省生物医药功能材料工程研究中心, 南京师范大学应用光化学重点实验室, 化学与材料科学学院, 南京 210097
  • 收稿日期:2012-12-18 出版日期:2013-09-10 发布日期:2013-08-30
  • 作者简介:王炳祥,男,博士,教授,主要从事有机化学研究.E-mail:wangbingxiang@njnu.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:21202101);江苏省高校自然科学基金(批准号:12KJD15008);江苏省高校优势学科建设工程项目资助.

Synthseis and Antibacterial Activities of Some 3-(2-Hydroxy-4, 6-dimethoxyphenyl)-5-aryl-isoxazolines

JIANG Yu-Liang, HAN Qiao-Rong, ZHOU Wen-Long, XU Zhu-Xiong, WANG Bing-Xiang   

  1. Jiangsu Province Key Laboratory of Biofunctional Materials, Jiangsu Province Engineering Research Center of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China
  • Received:2012-12-18 Online:2013-09-10 Published:2013-08-30

摘要:

以查尔酮衍生物为前体, 与盐酸羟胺在碱性条件下反应制得7个3-(2-羟基-4,6-二甲氧基苯基)-5-芳基异噁唑啉化合物(2a~2g), 产物经红外光谱、核磁共振谱、质谱和元素分析表征. 抑菌活性研究结果表明, 化合物2d和2e对大肠杆菌、金黄色葡萄球菌、枯草杆菌和绿脓杆菌均有一定抑制作用, 其中化合物2e对大肠杆菌、金黄色葡萄球菌表现出极好的抑菌活性.

关键词: 3-(2-羟基-4,6-二甲氧基苯基)-5-芳基异噁唑啉, 抑菌性, 大肠杆菌, 金黄色葡萄球菌

Abstract:

In the present paper, seven 3-(2-hydroxy-4,6-dimethoxyphenyl)-5-aryl-isoxazolines(2a—2g) were synthesized via the reaction of chalcone derivatives with hydroxylamine. All the synthesized compounds(2a—2g) were characterized by IR,1H NMR, MS and elemental analysis. The study on the antibacterial activity of these compounds against Escherichia coli, Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa indicated that compounds 2d and 2e had a certain inhibitory effect on all select strains while compound 2e showed good antimicrobial properties on E. coli and S. aureus.

Key words: 3-(2-Hydroxy-4,6-dimethoxyphenyl)-5-aryl-isoxazoline, Antibacterial activity, Escherichia coli, Staphylococcus aureus

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