高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

聚丙烯酰胺/聚L-谷氨酸苄酯接枝共聚物的合成及其胶束制备

吴秋华, 魏天柱, 梁芳, 宋溪明, 韩光喜, 张国林   

  1. 辽宁大学化学院, 绿色合成与先进材料制备化学辽宁省高校重点实验室, 沈阳 110036
  • 收稿日期:2008-02-20 修回日期:1900-01-01 出版日期:2008-08-10 发布日期:2008-08-10
  • 通讯作者: 张国林

Synthesis and Micellization of Polyacrylamide/Poly(γ-benzyl-L-glutamate) Graft Copolymer

WU Qiu-Hua, WEI Tian-Zhu, LIANG Fang, SONG Xi-Ming, HAN Guang-Xi, ZHANG Guo-Lin*   

  1. Key Laboratory of Green Synthesis and Preparative Chemistry of Advanced Materials, The Education Department of Liaoning Province, College of Chemistry, Liaoning University, Shenyang 110036, China
  • Received:2008-02-20 Revised:1900-01-01 Online:2008-08-10 Published:2008-08-10
  • Contact: ZHANG Guo-Lin

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摘要： 以聚丙烯酰胺(PAM)为大分子引发剂, 采用开环聚合方法, 在N,N-二甲基甲酰胺(DMF)中引发L-谷氨酸苄酯环内酸酐(BLG-NCA)聚合合成了两亲性聚丙烯酰胺/聚L-谷氨酸苄酯接枝共聚物(PAM-g-BLG), 采用IR, 1H NMR和GPC方法对共聚物结构进行了表征; 用芘作荧光探针, 研究了共聚物胶束的形成及其临界胶束浓度(cmc), 利用动态光散射(DLS)和透射电镜(TEM)研究了胶束的粒径分布和形态. 结果表明, PAM能够引发BLG-NCA开环聚合得到接枝共聚物, 在一定条件下接枝共聚物能够形成球形的稳定胶束, cmc值和胶束粒径随着共聚物中疏水性聚L-谷氨酸苄酯(PBLG)链段含量的增加而减小.

关键词: 聚L-谷氨酸苄酯, 两亲性接枝共聚物, 开环聚合, 临界胶束浓度

Abstract: Polyacrylamide/poly(γ-benzyl-L-glutamate)(PAM-g-BLG) amphiphilic graft copolymers were synthesized by ring-opening polymerization of N-carboxy-γ-benzyl-L-glutamate anhydride(BLG-NCA) in N,N-dimethylformamide(DMF) initiated by polyacrylamide. The structure of the copolymers was determined via IR, 1H NMR and GPC. The fluorescence technique was used to determine micellization and the critical micelle concentrations(CMC) of copolymer in water. The diameter and distribution of micelles were characte-rized by DLS and its shape was observed by TEM. The results show that BLG-NCA could be initiated by polyacrylamide to produce graft copolymer. The round nano-micells were formed by these copolymers in water. The CMC of copolymer solution and the size of micell were reduced with the increase of the proportion of hydrophobic parts.

Key words: Poly(γ-benzyl-L-glutamate), Amphiphilic graft copolymer, Ring-opening polymerization, Critical micelle concentration

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