高等学校化学学报

高等学校化学学报 ›› 1990, Vol. 11 ›› Issue (11): 1295.

• 研究简报 • 上一篇    下一篇

三氯锗取代丙酰氢化噻唑-2-硫酮类化合物及其水解产物的合成

黄化民, 李叶芝, 郝素娥, 王玉平   

  1. 吉林大学化学系, 130023
  • 收稿日期:1989-04-14 出版日期:1990-11-24 发布日期:1990-11-24
  • 通讯作者: 李叶芝

Synthesis of N-(Trichlorpgermyl) Substituted Propionyl Hydrothiazol-2-Thiones Compounds and Their Hydrolysis Products

Huang Huamin, Li Yezhi, Hao Sue, Wang Yuping   

  1. Department of Chemistry, Jilin University, Changchun, 130023
  • Received:1989-04-14 Online:1990-11-24 Published:1990-11-24

PDF (PC)

被引次数

1

摘要： 某些有机锗化物,例如β-羧乙基锗倍半氧化物及其衍生物能诱发干扰素,对癌症有一定疗效,日本专利报道丙酰胺基锗倍半氧化物及其衍生物也具有抗癌活性[2,3],白明章等曾合成丙酰芳胺基锗倍半氧化物[4]。

关键词: 三氯锗取代丙酰基四氢噻唑-2-硫酮, 三氯锗取代丙酰基苯并二氢噻唑-2-硫酮, &beta, -取代丙酰四氢噻唑-2-硫酮基锗倍半氧化物, &beta, -取代丙酰苯并二氢噻唑-2-硫酮基锗倍半氧化物

Abstract: In this paper trichlorogermyl propionyl chlorides Ⅱa-c were prepared by the reaction of trichlorogermyl propionic acid Ⅰa-c with sulfenyl dichloride in 86%～9.1% yields.The compounds Ⅱa-c reacted with thiazolidine-2-thione or 2-mercaptobcnzothiazolc to form the N-(trichlorogermyl) substituted propionyl-thiazolidine-2-thione Ⅲu-c and N-(trichlorogermyl) substituted propionyl benzothiazoline-2-thione IVa-c in 62.9%～97.7% yields.The β-substituted propionyl thiazolidine-2-thionyl germanium sesquioxide Va-cand β-substituted propionyl benzothiazoline-2-thionyl germanium sesquioxide VIa-c were obtained by hydrolysis of compounds Ⅲa-c and Ⅲa-c in 44.0%～83.8% yields.The compounds Ⅱb-c, Ⅲa-c, Ⅳa-c, Ⅴa-c and VIa-c are new compounds.

Key words: N-(Trichlorogermyl) substituted propionyl thiazolidine-2-thione, N-(Trichlorogcrmyl) substituted propionyl benzothiazoline-2-thione, β-Substitutcd propionyl thiazolidine-2-thionyl germanium sesquioxide, β-substituted propionyl benzothiazoline

TrendMD: