高等学校化学学报 ›› 2022, Vol. 43 ›› Issue (12): 20220430.doi: 10.7503/cjcu20220430
收稿日期:
2022-06-17
出版日期:
2022-12-10
发布日期:
2022-07-19
通讯作者:
程震
E-mail:zcheng@simm.ac.cn
基金资助:
CHANG Tonghang1,3, CHENG Zhen1,2,3()
Received:
2022-06-17
Online:
2022-12-10
Published:
2022-07-19
Contact:
CHENG Zhen
E-mail:zcheng@simm.ac.cn
Supported by:
摘要:
将诊断与治疗功能结合为一体是当前应对癌症的一种新兴策略. 诊疗一体化作为一种潜在的新型医学诊治方式, 在快速获得体内信息、 改善生物分布、 减少剂量和降低毒副作用等方面具有潜在的应用前景. 荧光成像被广泛应用于医学诊断, 近年来近红外荧光成像技术得到飞速发展, 在活体成像方面具有较好的穿透深度和成像分辨率. 本文综合评述了部分整合荧光成像和化疗的有机单分子诊疗试剂的相关研究, 并对诊疗一体化探针的未来研究进行了展望.
中图分类号:
TrendMD:
常通航, 程震. 整合荧光成像和化疗的有机小分子诊疗探针的研究进展. 高等学校化学学报, 2022, 43(12): 20220430.
CHANG Tonghang, CHENG Zhen. Research Progress of Organic Small Molecule Theranostic Probes Integrating Fluorescence Imaging and Chemotherapy. Chem. J. Chinese Universities, 2022, 43(12): 20220430.
Fig.1 Structures of Doxo⁃S⁃S⁃Fol and Doxo⁃C⁃C⁃Fol(A) and fluorescence microscopy images of A549 cells stained by Doxo⁃S⁃S⁃Fol at different intervals(B)[20]Copyright 2011, American Chemical Society.
Fig.2 Activation principle and imaging property of DCM⁃S⁃CPT[30](A) Reaction mechanism of DCM-S-CPT breaking disulfide bond under GSH; (B) in vivo fluorescence imaging of tumor-bearing mice at various time after intravenous injection of DCM-C-CPT; (C) fluorescence imaging of in vivo biodistribution of DCM-C-CPT; (D) in vivo fluorescence imaging of tumor-bearing mice at various time after intravenous injection of DCM-S-CPT; (E) fluorescence imaging of in vivo biodistribution of DCM-S-CPT. Copyright 2014, American Chemical Society.
Fig.5 Structures and imaging property of F16 derivatives[42](A) Structures of F16 derivatives; (B) fluorescence imaging of mitochondrial co-localization of 5BMF in different cell lines; (C) fluorescence imaging of tumor-bearing mice after intravenous injection of 5BMF for 2 h. Copyright 2019, the Royal Society of Chemistry.
Fig.6 Structure and imaging property of Cy7[43](A) Structure of organic theranostic probe Cy7; (B) fluorescent images of KB and A549 cells treatedwith Cy7 at various time(0, 5, 10 and 20 min). Copyright 2013, American Chemical Society.
Fig.7 Theranostic property of cyanine based probes[49](A) Structures of organic theranostic probes of IR-780NM, NIRG and NMI; (B) near-infrared fluorescence imaging of the mice after intratumoral injection of NMI; (C) the tumor size variation curve of the NMI-treated group and the normal saline group. Copyright 2015, American Chemical Society.
Fig.8 Activation principle of Cy⁃S⁃CPT and imaging property of Cy⁃S⁃CPT, Cy⁃C⁃CPT and CyA⁃K[50](A) Proposed mechanism of Cy-S-CPT activated by GSH; (B—D) in vivo bioimaging of tumor-bearing mice at various time(0.25, 0.5, 1, 2, 4, 8 and 24 h) after intravenous injection of PEG-PLA/Cy-S-CPT(B), PEG-PLA/Cy-C-CPT(C) and PEG-PLA/CyA-K(D) at a dose of 5 µmol/kg. Copyright 2016, the Royal Society of Chemistry.
Fig.10 Structure and imaging property of PNPS[52](A) The design of PNPS and proposed activation mechanism; (B) in vivo near-infrared fluorescence imaging of HCT116 tumor-bearing mice at different time(0, 1, 3, 6, 12 and 24 h) after intravenous injection of PNPS at the dose of 4.31 mg/kg. Copyright 2017, the Royal Society of Chemistry.
Fig.11 Synthetic route and imaging property of H4⁃PEG⁃Glu[53](A) Synthetic route of H4-PEG-Glu; (B) in vivo near-infrared second-region fluorescence imaging of acute myeloid leukemia PDX mice and normal mice at different times(3, 6 and 9 h) after intravenous injection of H4-PEG-Glu respectively. Reproduced from Ref.[53] with permission from the Royal Society of Chemistry.
1 | Sung H., Ferlay J., Siegel R. L., Laversanne M., Soerjomataram I., Jemal A., Bray F., CA: A Cancer J. Clin., 2021, 71(3), 209—249 |
2 | Kulik L., El⁃Serag H. B., Gastroenterology, 2019, 156(2), 477—491 |
3 | Hambley T. W., Cancer Res., 2009, 69(4), 1259—1261 |
4 | Markham M. J., Wachter K., Agarwal N., Bertagnolli M. M., Chang S. M., Dale W., Diefenbach C. S. M., Rodriguez⁃Galindo C., George D. J., Gilligan T. D., Harvey R. D., Johnson M. L., Kimple R. J., Knoll M. A., LoConte N., Maki R. G., Meisel J. L., Meyerhardt J. A., Pennell N. A., Rocque G. B., Sabel M. S., Schilsky R. L., Schneider B. J., Tap W. D., Uzzo R. G., Westin S. N., J. Clin. Oncol., 2020, 38(10), 1081—1101 |
5 | Etzioni R., Urban N., Ramsey S., McIntosh M., Schwartz S. , Reid B., Radich J., Anderson G., Hartwell L., Nat. Rev. Cancer, 2003, 3(4), 243—252 |
6 | Okamoto S., Shiga T., Tamaki N., Molecules, 2021, 26(8), 2232 |
7 | Smith A. M., Mancini M. C., Nie S. M., Nat. Nanotechnol., 2009, 4(11), 710—711 |
8 | Frangioni J. V., Curr. Opin. Chem. Biol., 2003, 7(5), 626—634 |
9 | Diao S., Hong G. S., Antaris A. L., Blackburn J. L., Cheng K., Cheng Z., Dai H. J., Nano Res., 2015, 8(9), 3027—3034 |
10 | Hemmer E., Benayas A., Légaré F., Vetrone F., Nanoscale Horiz., 2016, 1(3), 168—184 |
11 | Li L., Dong X. G., Li J. R., Wei J., Dyes and Pigments, 2020, 183, 108756 |
12 | Gong H., Peng R., Liu Z., Adv. Drug Deliv. Rev., 2013, 65(15), 1951—1963 |
13 | Gil H. M., Price T. W., Chelani K., Bouillard J. S. G., Calaminus S. D. J., Stasiuk G. J., iScience, 2021, 24(3), 102189 |
14 | Yu Z. F., Eich C., Cruz L. J., Front. Chem., 2020, 8, 496 |
15 | Kumar R., Shin W. S., Sunwoo K., Kim W. Y., Koo S., Bhuniya S., Kim J. S., Chem. Soc. Rev., 2015, 44(19), 6670—6683 |
16 | Chen X. Y., Liu Y. S., He M., Shangguan P., Han L. L., Wang J. F., Shi B. Y., Chem. J. Chinese Universities, 2021, 42(11), 3310—3320 |
陈晓宇, 刘义升, 何牧, 上官萍, 韩璐璐, 王杰菲, 师冰洋. 高等学校化学学报, 2021, 42(11), 3310—3320 | |
17 | Tang L., Zeng X. D., Zhou H., Gui C. H., Luo Q. L., Zhou W. Y., Wu J., Li Q. Q., Li Y., Xiao Y. L., Chem. Res. Chinese Universities, 2021, 37(4), 934—942 |
18 | Li X. L., Jiang M. Y., Zeng S. J., Liu H. R., Theranostics, 2019, 9(13), 3866—3878 |
19 | Li J., Liu Y., Xu Y. L., Li L., Sun Y., Huang W., Coord. Chem. Rev., 2020, 415, 213318 |
20 | Santra S., Kaittanis C., Santiesteban O. J., Perez J. M., J. Am. Chem. Soc., 2011, 133(41), 16680—16688 |
21 | Sies H., Free Radic. Biol. Med., 1999, 27(9/10), 916—921 |
22 | Guo Z. Q., Zhu W. H., Tian H., Chem. Commun., 2012, 48(49), 6073—6084 |
23 | Shao A. D., Xie Y. S., Zhu S. J., Guo Z. Q., Zhu S. Q., Guo J., Shi P., James T. D., Tian H., Zhu W. H., Angew. Chem. Int. Ed., 2015, 54(25), 7275—7280 |
24 | Guo Z. Q., Zhu W. H., Shen L. J., Tian H., Angew. Chem. Int. Ed., 2007, 46(29), 5549—5553 |
25 | Jia X. B., Zhang Y. H., Zou Y., Wang Y., Niu D. C., He Q. J., Huang Z. J., Zhu W. H., Tian H., Shi J. L., Li Y. S., Adv. Mater., 2018, 30(30), 1704490 |
26 | Venkatakrishnarao D., Narayana Y. S. L. V., Mohaiddon M. A., Mamonov E. A., Mitetelo N., Kolmychek I. A., Maydykovskiy A. I., Novikov V. B., Murzina T. V., Chandrasekar R., Adv. Mater., 2017, 29(15), 1605260 |
27 | Fu W., Yan C. X., Guo Z. Q., Zhang J. J., Zhang H. Y., Tian H., Zhu W. H., J. Am. Chem. Soc., 2019, 141(7), 3171—3177 |
28 | Sun W., Fan J. L., Hu C., Cao J. F., Zhang H., Xiong X. Q., Wang J. Y., Cui S., Sun S. G., Peng X. J., Chem. Commun., 2013, 49(37), 3890—3892 |
29 | Zhu W., Huang X. M., Guo Z. Q., Wu X. M., Yu H. H., Tian H., Chem. Commun., 2012, 48(12), 1784—1786 |
30 | Wu X. M., Sun X. R., Guo Z. Q., Tang J. B., Shen Y. Q., James T. D., Tian H., Zhu W. H., J. Am. Chem. Soc., 2014, 136(9), 3579—3588 |
31 | Wang Z. Q., Wu H., Liu P. L., Zeng F., Wu S. Z., Biomaterials, 2017, 139, 139—150 |
32 | Zhang J. F., Lim C. S., Bhuniya S., Cho B. R., Kim J. S., Org. Lett., 2011, 13(5), 1190—1193 |
33 | Zhu B. C., Zhang X. L., Li Y. M., Wang P. F., Zhang H. Y., Zhuang X. Q., Chem. Commun., 2010, 46(31), 5710—5712 |
34 | He H. R., Mortellaro M. A., Leiner M. J. P., Fr aatz R. J., Tusa J. K., J. Am. Chem. Soc., 2003, 125(6), 1468—1469 |
35 | Lee M. H., Kim J. Y., Han J. H., Bhuniya S., Sessler J. L., Kang C., Kim J. S., J. Am. Chem. Soc., 2012, 134(30), 12668—12674 |
36 | Kim T., Jeon H. M., Le H. T., Kim T. W., Kang C., Kim J. S., Chem. Commun., 2014, 50(57), 7690—7693 |
37 | Wu J., Huang R., Wang C. C., Liu W. T., Wang J. Q., Weng X. C., Tian T., Zhou X., Org. Biomol. Chem., 2013, 11(4), 580—585 |
38 | Rotem R., Heyfets A., Fingrut O., Blickstein D., Shaklai M., Flescher E., Cancer Res., 2005, 65(5), 1984—1993 |
39 | Fantin V. R., Berardi M. J., Scorrano L., Korsmeyer S. J., Leder P., Cancer Cell, 2002, 2(1), 29—42 |
40 | Fantin V. R., Leder P., Cancer Res., 2004, 64(1), 329—336 |
41 | Wu S., Cao Q. Z., Wang X. L., Cheng K., Cheng Z., Chem. Commun., 2014, 50(64), 8919—8922 |
42 | Chen H., Wang J., Feng X., Zhu M., Hoffmann S., Hsu A., Qian K., Huang D. J., Zhao F., Liu W., Zhang H. M., Cheng Z., Chem. Sci., 2019, 10(34), 7946—7951 |
43 | Yang Z., Lee J. H., Jeon H. M., Han J. H., Park N., He Y., Lee H., Hong K. S., Kang C., Kim J. S., J. Am. Chem. Soc., 2013, 135(31), 11657—11662 |
44 | Zhang E. L., Luo S. L., Tan X., Shi C. M., Biomaterials, 2014, 35(2), 771—778 |
45 | Behin A., Hoang⁃Xuan K., Carpentier A. F., Delattre J. Y., Lancet, 2003, 361(9354), 323—331 |
46 | Wrensch M., Minn Y., Chew T., Bondy M., Berger M. S., Neuro⁃Oncol., 2002, 4(4), 278—299 |
47 | Wu J. B. Y., Shi C. H., Chu G. C. Y., Xu Q. J., Zhang Y., Li Q. L., Yu J. S., Zhau H. Y. E., Chung L. W. K., Biomaterials, 2015, 67, 1—10 |
48 | Shi C. H., Wu J. B., Chu G. C. Y., Li Q. L., Wang R. X., Zhang C. Q., Zhang Y., Kim H. L., Wang J., Zhau H. Y. E., Pan D. F., Chung L. W. K., Oncotarget, 2014, 5(20), 10114—10126 |
49 | Wu J. B., Lin T. P., Gallagher J. D., Kushal S., Chung L. W. K., Zhau H. Y. E., Olenyuk B. Z., Shih J. C., J. Am. Chem. Soc., 2015, 137(6), 2366—2374 |
50 | Ye M. Z., Wang X. H., Tang J. B., Guo Z. Q., Shen Y. Q., Tian H., Zhu W. H., Chem. Sci., 2016, 7(8), 4958—4965 |
51 | Guo Z. Q., Ma Y. G., Liu Y. J., Yan C. X., Shi P., Tian H., Zhu W. H., Sci. China Chem., 2018, 61(10), 1293—1300 |
52 | Liu H. W., Hu X. X., Li K., Liu Y. C., Rong Q. M., Zhu L. M., Yuan L., Qu F. L., Zhang X. B., Tan W. H., Chem. Sci., 2017, 8(11), 7689—7695 |
53 | Zheng Y. J., Li Q. Q., Wu J., Luo Z. Y., Zhou W. Y., Li A. G., Chen Y. L., Rouzi T., Tian T., Zhou H., Zeng X. D., Li Y., Cheng X. D., Wei Y. C., Deng Z. X., Zhou F. L., Hong X. C., Chem. Sci., 2021, 12(5), 1843—1850 |
54 | Chang T. H., Qiu Q., Ji A. Y., Qu C. R., Chen H., Cheng Z., Biomaterials, 2022, 287, 121670 |
[1] | 刘树威, 晋皓, 尹万忠, 张皓. 用于卵巢癌化疗-光热联合治疗的吉西他滨/聚吡咯复合纳米粒子[J]. 高等学校化学学报, 2022, 43(8): 20220345. |
[2] | 张开翔, 刘军杰, 宋巧丽, 王丹钰, 史进进, 张海悦, 李景虹. 基于DNA纳米花的细胞自噬基因沉默用于增敏抗肿瘤化疗[J]. 高等学校化学学报, 2020, 41(7): 1461. |
[3] | 金新天, 刘刚, 李君哲, 孙丽丽, 王俊荣, 李俊锋, 李沛, 陈文庆, 王强, 佟倜. 透明质酸修饰的介孔二氧化硅包覆金纳米棒的制备及在肿瘤化疗-热疗联合治疗中的应用[J]. 高等学校化学学报, 2016, 37(2): 224. |
[4] | 刘宇炜, 郭卓. 聚多巴胺-阿霉素纳米颗粒对癌细胞的化疗-光热治疗协同作用[J]. 高等学校化学学报, 2015, 36(7): 1389. |
阅读次数 | ||||||
全文 |
|
|||||
摘要 |
|
|||||