高等学校化学学报

高等学校化学学报 ›› 2009, Vol. 30 ›› Issue (9): 1744.

• 研究论文 • 上一篇    下一篇

温度诱导双水相体系中扁桃酸的手性识别研究

邢健敏, 李芬芳   

  1. 中南大学化学化工学院, 长沙 410083
  • 收稿日期:2009-01-12 出版日期:2009-09-10 发布日期:2009-09-10
  • 通讯作者: 李芬芳, 女, 博士, 教授, 从事双水相萃取及手性拆分研究. E-mail: lfflqq@mail.csu.edu.cn
  • 基金资助:

    湖南省自然科学重点基金(批准号: 08jj3023)和中南大学优秀博士学位论文(批准号: 2008yb036)资助.

Chiral Recognition of Mandelic Acid by Temperature Induced Double Aqueous Phases System

XING Jian-Min, LI Fen-Fang*   

  1. School of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • Received:2009-01-12 Online:2009-09-10 Published:2009-09-10
  • Contact: LI Fen-Fang. E-mail: lfflqq@mail.csu.edu.cn
  • Supported by:

    湖南省自然科学重点基金(批准号: 08jj3023)和中南大学优秀博士学位论文(批准号: 2008yb036)资助.

PDF (PC)

被引次数

23

摘要：

以双水相体系为手性识别体系, 研究了异丙醇/盐和TritonX-114温度双水相体系中扁桃酸的分配行为. 对于醇/盐体系, 扁桃酸均倾向于分配在醇相中, 不适合作为手性识别系统; 而对于TritonX-114温度双水相体系, 扁桃酸富集于水相, 适合作为手性识别系统. 以L-酒石酸正戊酯和β-环糊精作为手性识别剂, 对TritonX-114/L-酒石酸正戊酯、TritonX-114/L-酒石酸正戊酯/茶皂素和TritonX-114/β-环糊精3个识别体系的研究发现, TritonX-114/L-酒石酸正戊酯/茶皂素和TritonX-114/β-环糊精体系中, 手性识别效果明显, 最佳分离体系为: 茶皂素含量0.51 mmol, L-酒石酸正戊酯含量1.4 mmol, 温度55 ℃, 最大分离因子1.29.

关键词: 双水相体系; 手性识别; 温度诱导

Abstract:

The partitioning behavior of mandelic acid was studied on the isopropyl alcohol/salt and TritonX-114 temperature induced system. The results show that the mandelic acid tends to exist in the isopropyl alcohol phase of the isopropyl alcohol/salt system, and in the water phase of the TritonX-114 temperature induced system, so the TritonX-114 temperature induced system was used as chiral recognition system. The chiral recognition of mandelic acid was investigated in the TritonX-114/n-amyl-L-tartrate/teasaponin and TritonX-114/β-CD system. Several factors were studied such as content of teasaponin, temperature. The results show that the TritonX-114/n-amyl-L-tartrate/teasaponin system is better than the TritonX-114/β-CD system. The separation factor increased with the teasaponin and temperature increased, and the optimal chiral recognition condition of double aqueous phases system was obtained, the content of teasaponin was 0.51 mmol, the n-amyl-L-tartrate was 1.4 mmol, temperature was 55 ℃. The largest separation factor was 1.29.

Key words: Double aqueous phases system; Chiral recognition; Temperature induced

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