高等学校化学学报

高等学校化学学报

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新型温度敏感性自组装胶束P(NiPAAm-co-DMAA)-co-P(L-Ala)的合成和性能

王海青, 俞玫, 鲍军波, 宋存先   

  1. 中国医学科学院北京协和医学院, 生物医学工程研究所, 天津市生物材料重点实验室, 天津 300192
  • 收稿日期:2008-04-17 修回日期:1900-01-01 出版日期:2009-01-10 发布日期:2009-01-10
  • 通讯作者: 宋存先

Synthesis and Properties of Novel Temperature-sensitive Self-assemble Nanomicelles of P(NiPAAm-co-DMAA)-co-P(L-Ala)

WANG Hai-Qing, YU Mei, BAO Jun-Bo, SONG Cun-Xian*   

  1. Institute of Biomedical Engineering, Chinese Academy of Medical Sciences Peking Union Medical College, Tianjin 300192, China
  • Received:2008-04-17 Revised:1900-01-01 Online:2009-01-10 Published:2009-01-10
  • Contact: SONG Cun-Xian

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摘要： 通过原子转移自由基聚合(ATRP)合成了一种带有活性—NH2基团的温度敏感性亲水型共聚物P(NiPAAm-co-DMAA), 并将其作为引发剂, 合成了P(NiPAAm-co-DMAA)-co-P(L-Ala), 其分子量分布(PDI)在1.3左右. 聚合物通过自组装形成纳米胶束. 透射电镜(TEM)结果表明, 胶束大小200~300 nm, 具有明显的核壳结构. 共聚物的最低临界溶解温度(LCST)为45.5 ℃. 温度低于LCST时, 聚合物溶解形成胶束; 高于LCST时, 胶束解离, 聚合物不溶. 聚合物对温度的响应是快速而可逆的.

关键词: 温度敏感, 自组装胶束, P(NiPAAm-co-DMAA)-co-P(L-Ala)

Abstract: A novel temperature-sensitive amphiphilic copolymer of P(NiPAAm-co-DMAA) with active —NH2 group was synthesized by ATRP, which was used as initiator of amino acid polymerization. The PDI of P(NiPAAm-co-DMAA)-co-P(L-Ala) is about 1.3. This polymer could form temperature-sensitive micelle by self-assembly. The diameter and distribution of micelle were observed by TEM. The results show that the siza of micelle is about 200—300 nm and the micelle has obvious core-shell structure. LCST of copolymer is 45.5 ℃. When temperature is under LCST, the copolymer is soluble and form temperature-sensitive micelle. When temperature is above LCST, the micelle dissociate and copolymer is insoluble. Its response to temperature is quickly and reversible.

Key words: Temperature-sensitive, Self-assembly micelle, P(NiPAAm-co-DMAA)-co-P(L-Ala)

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