高等学校化学学报

高等学校化学学报

• 研究论文 • 上一篇    下一篇

以Pluronics®为第二组分制备聚乳酸峰窝状规整多孔薄膜

孙巍, 唐越超, 计剑   

  1. 浙江大学高分子科学与工程学系, 教育部高分子合成与功能构造重点实验室, 杭州 310027
  • 收稿日期:2006-12-05 修回日期:1900-01-01 出版日期:2007-07-10 发布日期:2007-07-10
  • 通讯作者: 计剑

Preparation of Ordered and Porous Honeycomb Structure Film of Poly(lactic acid) with Pluronics® as the Second Component

SUN Wei, TANG Yue-Chao, JI Jian*   

  1. Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China
  • Received:2006-12-05 Revised:1900-01-01 Online:2007-07-10 Published:2007-07-10
  • Contact: JI Jian

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摘要：

以聚乳酸(PLA)为成膜材料, 以两亲三嵌段共聚物PEO-PPO-PEO(Pluronics®)为第二组分, 利用水辅助法成功地制备了聚乳酸蜂窝状多孔膜. 研究了环境湿度、溶液浓度和所用PLA分子量对多孔膜结构的影响. 结果表明, 加入第二组分PEO-PPO-PEO能有效地促进规整蜂窝结构的形成. 蛋白质吸附实验结果进一步证明了PEO-PPO-PEO组分在孔洞内壁的富集, 由此构建了阻抗蛋白质吸附的图案化功能结构表面.

关键词: 水辅助法组装, 蜂窝状结构, 聚乳酸, 两亲三嵌段共聚物(PEO-PPO-PEO)

Abstract:

A porous poly(lactic acid) film with a well-ordered honeycomb structure was prepared via the breath-figure method. The addition of amphiphilic Pluronics® was proved to be able to benefit a lot to fabricate the well-ordered honeycomb-patterned film. Several influencing factors including atmosphere humidity, solution concentration and the molecular weight were investigated. The fluorescein isothiocyanate labelled bovine serum albumin(FITC-BSA) was used as the probes to investigate the protein absorption onto the pattern film. Fluorescence images showed the corresponding honeycomb patterns, indicating that the honeycomb-patterned films with protein-resistant pores could be successfully constructed with Pluronics® as the second component.

Key words: Water-assisted fabrication, Honeycomb structure, Poly(lactic acid), PEO-PPO-PEO

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