高等学校化学学报

高等学校化学学报

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肉芝软珊瑚Sarcophyton crassocaule中新的多羟基甾醇的分离

张翠仙1,2, 阎素君1, 张广文3, 苏镜娱1, 曾陇梅1   

    1. 中山大学化学与化工学院, 广州 510275;
    2. 广州中医药大学中药学院, 广州 510405;
    3. 暨南大学食品科学与工程系, 广州 510632
  • 收稿日期:2006-05-06 修回日期:1900-01-01 出版日期:2007-04-10 发布日期:2007-04-10
  • 通讯作者: 曾陇梅

Isolation of New Polyhydroxylated Sterol from Soft Coral Sarcophyton crassocaule Mosre

ZHANG Cui-Xian1,2, YAN Su-Jun1, ZHANG Guang-Wen3, SU Jing-Yu1, ZENG Long-Mei1*   

    1. School of Chemistry and Chemical Engineering , Sun Yat Sen University, Guangzhou 510275, China;
    2. School of Taditional Chinese Medicine, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510405, China;
    3. Department of Food Science and Technology, Jinan University, Guangzhou 510632, China
  • Received:2006-05-06 Revised:1900-01-01 Online:2007-04-10 Published:2007-04-10
  • Contact: ZENG Long-Mei

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摘要： 报道了从三亚海域的一种肉芝软珊瑚Sarcophyton crassocaule Mosre中分离得到2个多羟基甾醇1和2. 通过波谱分析等方法测定了它们的化学结构, 化合物1为新化合物, 命名为Sarcrasterol. 化合物2为已知物[24ξ-methyl-colestane-3β,5β,6α,25-tetrol], 但其C24构型未确定, 通过X射线单晶衍射分析测定了其相对构型为24S.

关键词: 肉芝软珊瑚, 次生代谢产物, 多羟基甾醇, 细胞毒性

Abstract: In our continuing search of discovering bioactive substances from marine organisms, a sample of soft coral Sarcophyton crassocaule Mosre collected off the Sanya bay, China, was investigated. Two polyhydroxylated sterols 1 and 2 were isolated from the 95% ethanol extract of the sample by chromatography over silica gel. Compound 1, named sarcrasterol, was a new compound, its structure was established as(22R*,24ξ)-methyl-cholest-5-en-3β,22α,25,28-tetraol by spectroscopic methods. Compound 2, a known compound, was first obtained by Kobayashi, however, the relative configuration of C24 has not been determined yet. This paper reports the stereochemistry of compound 2 established as (24S*)-methyl cholest-3β,5β,6α,25-tetraol by means of X-ray single crystal diffraction analysis. Bioassay results show that compound 2 has a moderate activity against human tumor cell lines MGC-803 with an IC50 value of 23.0 μg/mL.

Key words: Soft coral, Sarcophyton crassocaule, Polyhydroxylated sterols, Cytotoxicity

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