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Corrole光敏剂在光动力治疗中的重原子效应

刘海洋1,2; 郭平叶1; 江柏荣2; 应晓3; 廖世军1; 麦乃歧4; 张启光2

  

  1. 1. 华南理工大学化学系, 广州 510641;
    2. 香港科技大学化学系, 香港;
    3. 华南理工大学应用物理系, 广州 510641;
    4. 香港浸会大学生物系, 香港
  • 收稿日期:2006-02-13 修回日期:1900-01-01 出版日期:2006-07-10 发布日期:2006-07-10
  • 通讯作者: 刘海洋;张启光

Heavy-atom Effect of Corrole Photosensitizer for Photodynamic Therapy

LIU Hai-Yang1,2*; GUO Ping-Ye1; KONG Pak-Wing2; YING Xiao3; LIAO Shi-Jun1; MAK Nai-Ki4; CHANG Chi-Kwong2*   

  1. 1. Department of Chemistry, South China University of Technology,
    Guangzhou 510641, China;
    2. Department of Chemistry, Hong Kong University of Science & Technology,
    Hong Kong, China;
    3. Department of Applied Physics, South China University of Technology,
    Guangzhou 510641, China;
    4. Department of Biology, Hong Kong Baptist University, Hong Kong, China
  • Received:2006-02-13 Revised:1900-01-01 Online:2006-07-10 Published:2006-07-10
  • Contact: LIU Hai-Yang; ZHANG Qi-Guang

摘要: 最近, 我们合成了一系列Corrole衍生物, 经过鼻咽癌(Nasopharyngeal carcinoma,NPC) 细胞的体外PDT试验后, 筛选出了一个具有优良PDT活性的Corrole光敏剂. 本文报道该类Corrole光敏剂在PDT中的重原子效应.

关键词: Corrole, 光敏剂, 鼻咽癌, 光动力治疗, 重原子效应

Abstract: 10-(2-Hydroxylphenyl)-5,15-bis(pentafluorophenyl) corrole was found to have a remarkable photocytotoxicity on nasopharyngeal carcinoma(NPC) cell line(Chang C. K. et al., Proc SPIE, 2006, Vol. 6139, p268). To explore the heavy-atom effect on corrole photosensitizer, an exact analogue of corole 1 with the modification of two heavy iodine atoms on its 10-phenyl group, 10-(2-hydroxyl-3,5-diiodophenyl)-5,15-bis(pentafluorophenyl)corrole, were synthesized.

Key words:

Corrole, Photosensitizer, Nasopharyngeal carcinoma, Photodynamic therapy, Heavy-atom effect

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