高等学校化学学报

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (3): 515.

• 研究论文 • 上一篇    下一篇

水溶性离子液体溶解磷脂脂质体的初步研究

孙春燕1,李迪1,王美佳1,唐江1,刘洋1,李景虹1,2   

  1. 1. 中国科学院长春应用化学研究所电分析化学国家重点实验室,长春 130022;
    2. 清华大学化学系,北京 100084
  • 收稿日期:2005-04-06 出版日期:2006-03-10 发布日期:2006-03-10
  • 通讯作者: 李景虹(1967年出生),男,博士,教授,博士生导师,主要从事电分析化学和生物纳米电化学研究. E-mail: jhli@mail.tsinghua.edu.cn
  • 基金资助:

    国家自然科学基金(批准号: 20125513,20435010)和美国李氏基金及国家百篇优秀博士论文基金资助.

Studies on  Solubilization of Phospholipid Liposomes by Water-miscible Ionic Liquids

SUN Chun-Yan1,LI Di1,WANG Mei-Jia1,TANG Jiang1,LIU Yang1,LI Jing-Hong1,2*   

  1. 1. State Key Laboratory of Electroanalytical Chemistry,Changchun Institute of Applied Chemistry, Chinese Academy of Sciences,Changchun 130022,China;
    2. Department of Chemistry,Tsinghua University,Beijing 100084,China
  • Received:2005-04-06 Online:2006-03-10 Published:2006-03-10

PDF (PC)

被引次数

8

摘要：

以磷脂脂质体为模拟生物膜,研究了新型绿色溶剂离子液体(ILs)对生物膜的影响. 对ILs-脂质体混悬液进行浊度、 差示扫描量热(DSC)和31P核磁共振(31P NMR)表征.  结果表明,1-正烷基-3-甲基-咪唑([Cnmim])阳离子的水溶性ILs与脂质体相互作用,能破坏脂质体的片层结构并溶解磷脂组分. [Cnmim]阳离子对脂质体的溶解起关键作用,阴离子类型和取代烷基链长对ILs的溶解性质也有显著影响. 初步探讨了ILs溶解脂质体的可行性机理.

关键词: 磷脂; 脂质体; 离子液体; 溶解; 浊度

Abstract:

AbstractThe effects of novel green solvents,ionic liquids(ILs),on the structures of phospholipid liposomes as model bio-membranes were studied.  The ILs-liposomes suspensions were characterized by turbidity,DSC and 31P NMR, and the results obtained demonstrate that  the interaction between water-miscible 1-n-alkyl-3-methylimidazolium ILs and  liposomes eventually led to the rupture of the liposome structures and the solubilization of the phospholipid components.  In the process,[Cnmim] cations played a crucial role in the solubilization of phospholipid liposomes,and the anion types and alkyl chain lengths also had influence on solubilizing properties of these ILs.  A possible mechanism involved in the ILs-induced solubilization of phospholipid liposomes was proposed.

Key words: Phospholipid; Liposome; Ionic liquid; Solubilization; Turbidity

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