高碘酸氧化肝素抑制P-选择素介导的A375细胞粘附

高等学校化学学报 ›› 2006, Vol. 27 ›› Issue (2): 236.

高碘酸氧化肝素抑制P-选择素介导的A375细胞粘附

魏民¹, 周义发¹, 田美红², 陈琳³, 曾宪录¹

1. 东北师范大学生命科学学院, 2. 体育学院, 长春 130024; 3. 长春市中心血站, 长春 130033

收稿日期:2005-05-23 出版日期:2006-02-10 发布日期:2006-02-10
通讯作者: 曾宪录(1959年出生), 男, 博士，教授, 博士生导师, 主要从事粘附分子方面的研究. E-mail: zengx779@nenu.edu.cn
基金资助:
教育部科学技术研究重点项目(批准号: 105060)和国家自然科学基金(批准号: 30570927)资助.

Periodate-oxidized Heparin Inhibiting P-selectin-mediated A375 Cell Adhesion

WEI Min¹, ZHOU Yi-Fa¹, TIAN Mei-Hong², CHEN Lin³, ZENG Xian-Lu ¹

1. School of Life Sciences, 2. School of Physical Education, Northeast Normal
University, Changchun 130024, China; 3. Changchun Blood Center, Changchun 130033, China

Received:2005-05-23 Online:2006-02-10 Published:2006-02-10
Contact: Zeng-Xian-Lu，E-mail: zengx779@nenu.edu.cn

摘要/Abstract

摘要：

摘要通过选择性化学修饰制备出具有低抗凝血活性的高碘酸氧化肝素, 并系统地分析了其抗肿瘤细胞粘附的活性. 研究结果表明, 具有低抗凝血活性的高碘酸氧化肝素仍然可以显著地抑制P-选择素介导的人恶性黑素瘤A375细胞与血小板间的粘附.

关键词: 关键词高碘酸氧化肝素; P-选择素; 血小板; 肿瘤转移

Abstract:

Abstract Numerous experiments show that heparin affects tumor metastasis in various ways, and one of the mechanisms by which heparin inhibits metastasis is by blocking the P-selectin-based interaction of platelets with tumor cells. However, heparin′s significant anticoagulant properties and the potential of bleeding complications may contraindicate its use as an anti\|metastasis compound. RO-heparin with low anticoagulant activity was tested as the inhibitor of human malignant melanoma A375 cells adhering to surface-immobilized platelets expressing P-selectin. Then we demonstrate that RO-heparin can block P-selectin-mediated A375 human melanoma cell adhesion, suggesting that it may has a potential value as a anti-metastatic, therapeutic agent.

Key words: KeywordsPeriodate-oxidized heparin; P-selectin; Platelet; Metastasis

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魏民周义发田美红陈琳曾宪录. 高碘酸氧化肝素抑制P-选择素介导的A375细胞粘附. 高等学校化学学报, 2006, 27(2): 236.

WEI Min, Zhou-Xi-Fa, Tian-Mei-Hong, Chen-Lin, Zeng-Xian-Lu. Periodate-oxidized Heparin Inhibiting P-selectin-mediated A375 Cell Adhesion. Chem. J. Chinese Universities, 2006, 27(2): 236.