高等学校化学学报

高等学校化学学报

• 研究简报 • 上一篇    下一篇

FTIR监测7-氟-2H-1,4-苯并噁嗪-3(4H)-酮的固相合成

黄明智1,2, 谌伟民1, 黄可龙3, 黄路2, 杨光富1   

    1. 华中师范大学化学系, 武汉 430079;
    2. 湖南化工研究院国家农药创制工程技术研究中心, 长沙 410007;
    3. 中南大学化学化工学院, 长沙 410083
  • 收稿日期:2005-10-13 修回日期:1900-01-01 出版日期:2006-11-10 发布日期:2006-11-10
  • 通讯作者: 杨光富

Monitoring of Solid-phase Synthesis of 7-Fluoro-2H-1,4-benzoxazine-3(4H)-ones via FTIR Spectroscopy

HUANG Ming-Zhi1,2, CHEN Wei-Min1, HUANG Ke-Long3, HUANG Lu2, YANG Guang-Fu1   

    1. Department of Chemistry, Central China Normal University, Wuhan 430079, China;
    2. National Engineering Research Center for Agrochemicals, Hunan Research Institute of Chemical Industry, Changsha 410007, China;
    3. College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China
  • Received:2005-10-13 Revised:1900-01-01 Online:2006-11-10 Published:2006-11-10
  • Contact: YANG Guang-Fu

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摘要： 我们已经合成了一系列具有生物活性的杂环取代苯并噁嗪酮类化合物, 为了构建一个苯并噁嗪酮类化合物的组合物库, 我们又探索出了一种固相合成7-氟-2H-1,4-苯并噁嗪-3(4H)-酮的方法, 并用FTIR技术成功地监测、优化了整个反应过程, 并根据得到的红外光谱图对反应动力学进行了探讨.

关键词: 组合化学, 固相有机合成, 红外光谱

Abstract: The solid-phase synthesis of 7-fluoro-1,4-2H-benzoxazine 3(4H)-ones on Wang resin via esterification, etherification, reduction, cyclization and cleavage reactions was studied, and the reaction conditions were optimized after analyzing the reaction kinetics according to the IR spectrum.

Key words: Combinatorial chemistry, Solid-phase organic synthesis, Infrared spectroscopy

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