高等学校化学学报

高等学校化学学报 ›› 2005, Vol. 26 ›› Issue (11): 2057.

• 研究论文 • 上一篇    下一篇

红葱中的新化学成分

邱峰, 徐金钟, 段文娟, 曲戈霞, 王乃利, 姚新生   

  1. 沈阳药科大学天然药物化学教研室, 沈阳110016
  • 收稿日期:2004-10-20 出版日期:2005-11-10 发布日期:2005-11-10
  • 基金资助:

    国家重点基础研究发展计划“九七三”计划(批准号:G1998051113)资助

New Constituents from Eleutherine americana

QIU Feng, XU Jin-Zhong, DUAN Wen-Juan, QU Ge-Xia, WANG Nai-Li, YAO Xin-Sheng   

  1. Department of Natural Products Chemistry,Shenyang Pharmaceutical University,Shenyang 110016,China
  • Received:2004-10-20 Online:2005-11-10 Published:2005-11-10

PDF (PC)

被引次数

20

摘要： 通过正相和反相硅胶柱色以及高效液相色谱,从红葱60%乙醇提取物中分离得到3个新化合物,利用物理化学和光谱学方法鉴定了其结构,分别为9,9'-二羟基-8,8'-二甲氧基-1,1'-二甲基-1H,1H-['4,4']双[萘并(2,3-c)呋喃]-3,3'-二酮(1),6,8-二羟基-3,4-二甲氧基-1-甲基-蒽醌-2-羧酸甲酯(2),2-乙酰基-3,6,8-三羟基-1-甲基蒽醌(3).这3个化合物均能不同程度地诱导稻瘟霉菌丝变形,其最小变形质量浓度(Mini-mummorphologicaldeformationmassconcentration,MMDC)分别为145.8,50.2和124.8μg/mL.利用MTT法测定了化合物抑制人类红白血细胞株K562细胞生长的活性,化合物2的IC50为49.1μg/mL.

关键词: 红葱, 生物活性, 稻瘟霉菌, 人类红白血细胞株

Abstract: Three new constituents were isolated from Eleutherine americana Merr.et K.Heyne(Hong-cong)by means of silica gel,ODS column chromatography and high performance liquid chromatography(HPLC).They were identified as 9,9'-dihydroxy-8,8'- dimethoxy-1,1'-methyl-1H,1H'-\bi\funanyl]-3,3'-dione(1),6,8-dihydroxy-3,4-dimethoxy-1-methyl-anthraquinone-2-carboxylic acid methyl ester(2),2-acetyl-3,6,8-trihydroxy-1-methylanthraquinone(3) by physico-chemical propeties and spectral data,respectively.All three compounds showed weak activities against the growth of Pyricularia oryzae.The MMDC(Minimum morphological deformation mass concentration) was 145.8,50.2,124.8 μg/mL.Additionally,compound 2 also inhibited the proliferation of K562(human erythroleukemia) with IC50 value of 49.1 μg/mL.

Key words: Eleutherine americana, Bioactivity, Pyricularia oryzae, Human erythroleukemia

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