高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (4): 697.

• 研究论文 • 上一篇    下一篇

新型核磁成像对比剂──两种Gd@C82水溶性衍生物的弛豫性能研究

卢兴1, 徐建勋1, 施祖进1, 孙宝云1, 顾镇南1, 刘洪东2, 韩鸿宾2   

  1. 1. 北京大学化学与分子工程学院, 北京 100871;
    2. 北京大学第三医院放射科, 北京 100083
  • 收稿日期:2003-06-12 出版日期:2004-04-24 发布日期:2004-04-24
  • 通讯作者: 顾镇南(1936年出生),男,教授,博士生导师,从事碳纳米管和金属富勒烯方面的研究.E-mail:guzn@chem.pku.edu.cn E-mail:guzn@chem.pku.edu.cn
  • 基金资助:

    国家自然科学基金(批准号:20151002,90206048)资助

Studies on the Relaxivities of Novel MRI Contrast Agents──Two Water-soluble Derivatives of Gd@C82

LU Xing1, XU Jian-Xun1, SHI Zu-Jin1, SUN Bao-Yun1, GU Zhen-Nan1, LIU Hong-Dong2, HAN Hong-Bin2   

  1. 1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China;
    2. Irradiation Department of the Third Hospital, Peking University, Beijing 100083, China
  • Received:2003-06-12 Online:2004-04-24 Published:2004-04-24

摘要: 在(37±1)℃下,以1.5T自旋回波序列测得2种Gd@C82的水溶性衍生物[Gd@C82(OH)22和Gd@C82(OH)6(NHCH2CH2SO3H)8]水溶液的质子弛豫率分别为r1=42.3mmol-1·L·s-1,r2=90.9mmol-1·L·s-1;r1=4.5mmol-1·L·s-1,r2=8.9mmol-1·L·s-1.讨论了这2种衍生物的弛豫机理,并解释了二者弛豫能力差别的原因.

关键词: 金属富勒烯, 水溶性衍生物, 核磁成像对比剂, 弛豫率

Abstract: The water proton relaxivities of two water-soluble derivatives of Gd@C82 [Gd@C82 (OH)22 and Gd@C82 (OH)6(NHCH2CH2SO3H)8] were determined to be r1=42.3 mmol-1 ·L·s-1 , r2=90.9 mmol-1 ·L·s-1 ; r1=4.5 mmol-1 ·L·s-1 , r2=8.9 mmol-1 ·L·s-1 , respectively at (37±1) ℃ by a 1.5 T spin-echo method. The relaxation mechanism was discussed and the reason why the relaxivities of Gd@C82 (OH)22 is an order of magnitude higher than that of Gd@C82 (OH)6 (NHCH2CH2SO3H)8 were explained.

Key words: Endohedral metallofullerenes, Water-soluble derivatives, MRI contrast agent, Relaxivity

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