高等学校化学学报

高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (3): 451.

• 研究简报 • 上一篇    下一篇

锆基纤维素手性固定相直接拆分萘普生衍生物

敦惠娟1,2, 李永民1, 柳春辉1, 魏永巨2, 陈立仁1   

  1. 1. 中国科学院兰州化学物理研究所, 兰州 730000;
    2. 河北师范大学实验中心, 石家庄 050016
  • 收稿日期:2003-03-17 出版日期:2004-03-24 发布日期:2004-03-24
  • 通讯作者: 陈立仁(1937年出生),男,研究员,博士生导师,从事高效液相色谱基础和应用研究.E-mail;chenlr@ns.lzb.ac.cn E-mail:chenlr@ns.lzb.ac.cn
  • 基金资助:

    国家自然科学基金(批准号;20375045);中国科学院“百人计划”;科学技术部基础研究快速反应基金资助

Chiral Resolution of Naproxen and Its Derivatives on Chiral Stationary Phase of Cellulose Tris(3,5-dimethylphenylcarbamate)-Coated Zirconia

DUN Hui-Juan1,2, LI Yong-Min1, LIU Chun-Hui1, WEI Yong-Ju2, CHEN Li-Ren1   

  1. 1. Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China;
    2. Hebei Normal University, Central Laboratory, Shijiazhuang 050016, China
  • Received:2003-03-17 Online:2004-03-24 Published:2004-03-24

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被引次数

14

关键词: 纤维素-三(3, 5-二甲基苯基氨基甲酸酯)-ZrO2手性固定相, 萘普生及其衍生物, 手性分离, HPLC

Abstract: In this report the synthesis and characterization of chiral stationary phase of cellulose tris(3,5 dimethylphenylcarbamate) coated zirconia(CDMPC ZrO2 CSP) was described. Direct optical resolutions of acidic racemate naproxen and its derivatives on the phase were investigated. Surface property of zirconia affects the chiral separation of naproxen greatly. Naproxen could not be eluted from the column unless an acidic modifier was present in the mobile phase. However, good chiral resolutions were obtained for its ester derivatives. The influences of loading amount of stationary phase, molecular structure of compounds, type of alcohols as the modifier and their concentration in mobile phase on chiral resolution were studied. The chiral recognition mechanism of the chiral stationary phase was discussed.

Key words: Cellulose tris(3,5 dimethylphenylcarbamate) coated zirconia chiral stationary phase, Naproxen and its derivatives, Chiral separation, HPLC

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