高等学校化学学报 ›› 2004, Vol. 25 ›› Issue (11): 2171-2173.

• 研究快报 • 上一篇    下一篇

一个新的过氧化物酶模拟物的合成及抗白内障活性研究

王丽萍, 刘亚丽, 杨卉, 李惟   

  1. 吉林大学生命科学学院, 长春130023
  • 收稿日期:2004-03-17 出版日期:2004-11-24 发布日期:2004-11-24
  • 基金资助:

    国家自然科学基金(批准号:29704010)资助

Synthesis and Anti-cataract Activity of a Novel Peroxidase Mimetics

WANG Li-Ping, LIU Ya-Li, YANG Hui, LI Wei   

  1. College of Life Science, Jilin University, Changchun 130023, China
  • Received:2004-03-17 Online:2004-11-24 Published:2004-11-24

关键词: 白内障, 过氧化物酶模拟物, 短肽

Abstract: Cataracts are one of the most important causes of blindness. As the mechanism of oxidative damage to cataracts was understood, anti-oxidants, especially peroxidase mimetics, were used to develop the agents to protect the eye and cure cataracts. We have designed and synthesized a nonapeptide (DhHP-6) containing deuterohaemin and histidine, which showed a peroxidase activity by degrading H2O2 and tert-butyl hydroxyl radical in ascorbate-specific peroxidase test. The specific activity is 4.0×103 U/μmol with H2O2 and ascorbate as the substrate. DhHP-6 is capable of protecting cultured rat lenses from cataracts induced by galactose. In the absence of the DhHP-6 big change on lenses was observed.

Key words: Cataract, Peroxidase mimetics, Nonapeptide

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